Document Detail

Calcium entry blockade and agonist-mediated forearm vasoconstriction in hypertensive patients. Difference between nicardipine and verapamil.
MedLine Citation:
PMID:  2060535     Owner:  NLM     Status:  MEDLINE    
The interference by nicardipine and verapamil with the response to vasoactive stimuli, such as lower body negative pressure and angiotensin II, has been evaluated in the forearm of hypertensive patients. Forearm blood flow was monitored during the intraarterial infusion of either drug at rates equieffective on basal flow. Nicardipine blunted the peak forearm vasoconstrictor action of lower body negative pressure and a comparable result was obtained when angiotensin II was administered intraarterially. In spite of a comparable increase in forearm flow, nicardipine was more potent than verapamil in inhibiting vasoconstriction following both stimuli. Thus, nicardipine suppressed regional vascular reactivity, probably by blockade of the influx of extracellular calcium, in response to receptor activation, since both alpha-adrenergic and angiotensin II receptor-mediated vasoconstrictor responses were attenuated. However, the results of the comparison with an unrelated calcium entry blocker, such as verapamil, may suggest that nicardipine, and possibly other dihydropiridine derivatives, preferentially antagonize agonist-mediated vasoconstriction in the human forearm.
R Pedrinelli; S Taddei; G Panarace; M Spessot; A Salvetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  40     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM; S    
Hypertension Unit, University of Pisa, Italy.
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MeSH Terms
Angiotensin II / pharmacology*
Forearm / blood supply
Hypertension / physiopathology*
Lower Body Negative Pressure
Nicardipine / pharmacology*
Phentolamine / pharmacology
Propranolol / pharmacology
Vasoconstriction / drug effects*
Verapamil / pharmacology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 50-60-2/Phentolamine; 52-53-9/Verapamil; 525-66-6/Propranolol; 55985-32-5/Nicardipine

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