Document Detail


Calcium dynamics in vascular smooth muscle.
MedLine Citation:
PMID:  23384444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells. These signals vary with respect to their mechanisms of generation, temporal properties, and spatial distributions. The calcium signals discussed include calcium waves, junctional calcium transients, calcium sparks, calcium puffs, and L-type calcium channel sparklets. For each calcium signal we address underlying mechanisms, general properties, physiological importance, and regulation.
Authors:
Gregory C Amberg; Manuel F Navedo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  20     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-10     Completed Date:  2013-12-09     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-9     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / physiology
Calcium / metabolism*
Calcium Channels, L-Type / metabolism*
Calcium Signaling / physiology*
Humans
Muscle Proteins / metabolism*
Muscle, Smooth, Vascular / metabolism*
Grant Support
ID/Acronym/Agency:
1R01HL098200/HL/NHLBI NIH HHS; R01 HL098200/HL/NHLBI NIH HHS; T32 HL007828/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channels, L-Type; 0/Muscle Proteins; SY7Q814VUP/Calcium
Comments/Corrections

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