Document Detail

Calcium does not augment phenylephrine's hypertensive effects.
MedLine Citation:
PMID:  2344749     Owner:  NLM     Status:  MEDLINE    
Ca and phenylephrine, both of which increase mean arterial pressure (MAP), are often administered concurrently during resuscitation of critically ill patients. To determine whether the response to phenylephrine is potentiated by Ca administration, we studied eight adult patients 24 h after aortocoronary bypass surgery. Each patient received three doses of phenylephrine (150, 300, and 450 ng/kg.min), administered both with and without CaCl2 (5 mg/kg bolus followed by a 2-mg/kg.h infusion). Phenylephrine alone at 150, 300, and 450 ng/kg.min increased MAP by 2%, 6%, and 17%, respectively. Ca alone increased serum ionized Ca levels from 1.00 +/- .03 (SEM) to 1.20 +/- .02 mM (p less than .05) and increased MAP from 84 +/- 1 to 90 +/- 2 mm Hg (p less than .05), but had no effect on cardiac index (CI). When administered concurrently with Ca, phenylephrine at 150, 300, and 450 ng/kg.min increased MAP by 6%, 7%, and 13%, respectively. Phenylephrine had no effect on CI, pulmonary capillary wedge pressure, CVP, or heart rate whether or not it was administered with Ca. We conclude that concomitant Ca administration does not augment the hypertensive response to phenylephrine in normotensive patients recovering from open heart surgery.
J F Butterworth; R A Strickland; L J Mark; N D Kon; G P Zaloga
Related Documents :
954829 - Reduced hypotensive effect of clonidine after lesions of the nucleus tractus solitarii ...
3913379 - Haemodynamic effects of prazosin combinations during dynamic and isometric exercise.
2998809 - Cardiovascular effects of centrally perfused clonidine.
2414579 - Methods for measuring vascular and nonvascular alpha-receptor sensitivity in humans.
8281989 - Effect of ramipril on alpha-adrenoceptor-mediated oscillatory contractions in tail arte...
7138149 - Effect of clonidine and propranolol on venous smooth muscle from spontaneously hyperten...
7796639 - Radial asymmetry characterized the upper esophageal sphincter pressures.
3069499 - The haemodynamic value of external carotid artery collateral blood supply in carotid ar...
11353699 - Chronic endothelin-1 blockade reduces sympathetic nerve activity in rabbits with heart ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  18     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  603-6     Citation Subset:  AIM; IM    
Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects*
Calcium Chloride / administration & dosage*,  therapeutic use
Coronary Artery Bypass
Drug Synergism
Drug Therapy, Combination
Hemodynamics / drug effects
Hypotension / drug therapy,  etiology,  physiopathology
Middle Aged
Phenylephrine / administration & dosage*,  therapeutic use
Postoperative Complications
Reg. No./Substance:
10043-52-4/Calcium Chloride; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modified system outcome score and outcome index--method of monitoring patient care in a special care...
Next Document:  Influence of amikacin as the primary aminoglycoside on bacterial isolates in the intensive care unit...