Document Detail

Calcium distribution in the vessel wall and intima-media thickness of the human carotid arteries.
MedLine Citation:
PMID:  17466442     Owner:  NLM     Status:  MEDLINE    
Increased common carotid artery (CCA) intima-media thickness (IMT) measured by B-mode ultrasound is an early marker of the atherosclerotic process. Arterial calcification is not clearly understood. Using the particle-induced X-ray emission (PIXE) method, we have looked for the location in the artery wall where calcium accumulated in the early phase of atherosclerosis. Twelve segments of CCAs of deceased stroke patients were investigated. In-vivo, carotid duplex ultrasound was performed with bilateral CCA IMT measurement at plaque-free sections. During autopsy, segments of carotid arteries were collected and filled under pressure with a stained histologic embedding material. The frozen arteries were cut into 60-microm-thick slices. Calcium distribution maps from the segments of arteries were determined by PIXE method. IMT measured by ultrasound and calcium distribution maps measured by PIXE were compared. In our cross-sectional study, using the PIXE analysis and ultrasound images, we could demonstrate early calcium accumulation in the media layer. Our results have also shown a significant relationship between calcium content of distributional maps measured by PIXE analysis and corresponding IMT on B-mode ultrasound images of human CCAs.
Mária Tünde Magyar; Zita Szikszai; Zsófia Kertész; Sándor Molnár; Imre Uzonyi; Gusztáv Aron Szíki; László Csiba
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-27
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  33     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1171-8     Citation Subset:  IM    
Department of Neurology, University of Debrecen, Debrecen, Hungary.
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MeSH Terms
Aged, 80 and over
Calcinosis / metabolism,  pathology,  ultrasonography*
Calcium / analysis*
Carotid Artery, Common / chemistry,  pathology,  ultrasonography*
Carotid Stenosis / metabolism,  pathology,  ultrasonography*
Cross-Sectional Studies
Tunica Intima / pathology,  ultrasonography
Tunica Media / pathology,  ultrasonography
Ultrasonography, Doppler, Duplex / methods
Reg. No./Substance:

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