| Calcium deposition in the skin of a hemodialysis patient with widespread skin necrosis. | |
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MedLine Citation:
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PMID: 1805654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rapidly progressive skin necrosis involving large areas of the skin associated with extensive vascular calcification was observed in a 39-year-old male patient on chronic hemodialysis. Histological examination of the periphery of a skin ulcer showed that subepidermal arterioles were occluded with fibrin deposits and that calcification was demonstrated in subcutaneous small arteries and arterioles. Electron microscopically, electron-dense materials, granular, crystal-like, vacuolar, or laminated, were found not only in arterial walls of the periphery of an ulcer but also, to a lesser extent, in those of normal-appearing skin. The skin necrosis gradually healed with antiseptic topical treatments and the injection of recombinant erythropoietin. The relationship between the vascular lesions in hemodialysis patients and progressive skin necrosis is not well known, although a combination of local and systemic factors may play an important role in the development of vascular calcification and skin necrosis in uremic and hemodialysis patients. |
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Authors:
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J Tada; R Torigoe; K Shimoe; S Ohara; J Arata; K Ashizawa |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 13 ISSN: 0193-1091 ISO Abbreviation: Am J Dermatopathol Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-05-07 Completed Date: 1992-05-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 605-10 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Okayama University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcinosis / pathology* Humans Kidney Failure, Chronic / therapy Male Necrosis Renal Dialysis / adverse effects* Skin / pathology*, ultrastructure Skin Diseases / pathology* Skin Ulcer / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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