Document Detail

Calcium deposition in the skin of a hemodialysis patient with widespread skin necrosis.
MedLine Citation:
PMID:  1805654     Owner:  NLM     Status:  MEDLINE    
Rapidly progressive skin necrosis involving large areas of the skin associated with extensive vascular calcification was observed in a 39-year-old male patient on chronic hemodialysis. Histological examination of the periphery of a skin ulcer showed that subepidermal arterioles were occluded with fibrin deposits and that calcification was demonstrated in subcutaneous small arteries and arterioles. Electron microscopically, electron-dense materials, granular, crystal-like, vacuolar, or laminated, were found not only in arterial walls of the periphery of an ulcer but also, to a lesser extent, in those of normal-appearing skin. The skin necrosis gradually healed with antiseptic topical treatments and the injection of recombinant erythropoietin. The relationship between the vascular lesions in hemodialysis patients and progressive skin necrosis is not well known, although a combination of local and systemic factors may play an important role in the development of vascular calcification and skin necrosis in uremic and hemodialysis patients.
J Tada; R Torigoe; K Shimoe; S Ohara; J Arata; K Ashizawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  13     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-05-07     Completed Date:  1992-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-10     Citation Subset:  IM    
Department of Dermatology, Okayama University Medical School, Japan.
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MeSH Terms
Calcinosis / pathology*
Kidney Failure, Chronic / therapy
Renal Dialysis / adverse effects*
Skin / pathology*,  ultrastructure
Skin Diseases / pathology*
Skin Ulcer / pathology

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