Document Detail

Calcium chloride administration in normocalcemic critically ill patients.
MedLine Citation:
PMID:  6987039     Owner:  NLM     Status:  MEDLINE    
Ten normocalcemic critically ill patients who had experienced a decrease in cardiac index greater than or equal to 0.5 liter/min/m2 after incremental changes of PEEP received 7 mg/kg of CaCl2 as a slow iv bolus, followed by an infusion of 20 mg/kg CaCl2 over 60 min. Hemodynamic pressures and flow, oxygen uptake and transport, and blood chemistry variables were determined over a 120-min period. The results indicated that: (1) hemodynamic variables were not affected except for left ventricular stroke work index and mean blood pressure, which increased slightly; (2) both serum calcium and ionized calcium concentrations increased significantly, sometimes to dangerous levels; (3) colloid osmotic pressure and hemoglobin levels decreased slightly but consistently. In conclusion, CaCl2 administration failed to improve hemodynamic function depressed by PEEP. If CaCl2 can play a relevant role in the management of cardiovascular depression, further identification of appropriate doses and patients is necessary.
G C Carlon; W S Howland; R C Kahn; O Schweizer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  8     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Calcium / blood
Calcium Chloride / administration & dosage*
Cardiac Output
Critical Care*
Heart Rate / drug effects
Hemodynamics / drug effects
Middle Aged
Oxygen Consumption
Positive-Pressure Respiration
Reg. No./Substance:
0/Hemoglobins; 10043-52-4/Calcium Chloride; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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