| Calcium channels blockers and progression of kidney disease. | |
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MedLine Citation:
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PMID: 18067048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to compare regimens including calcium channel blockers (CCBs) to non-CCBs agents such as angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers (ARBs) regarding progression in nondiabetic chronic kidney disease (CKD). There was no difference in reaching serum creatinine concentration (Cr) to more than 7 mg/dL and/or commencing dialysis. The CCB group compared to non-CCBs displayed a higher mean Cr (as well as a higher rate of increase) and proteinuria. Medication with CCBs and younger age were associated with adverse renal function outcome. It is concluded that CCBs are less effective than ACEIs or ARBs on preserving renal function and ameliorating proteinuria in nondiabetic CKD. |
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Authors:
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Stavroula Ziakka; Nikolaos Kaperonis; Eleftheria Ferentinou; Filippos Karakasis; George Ntatsis; Christine Kourvelou; Nikolaos Papagalanis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Renal failure Volume: 29 ISSN: 0886-022X ISO Abbreviation: Ren Fail Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-03-07 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: United States |
Other Details:
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Languages: eng Pagination: 1003-12 Citation Subset: IM |
Affiliation:
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Nephrology Department, Red Cross Hospital, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use Blood Pressure / drug effects* Calcium Channel Blockers / pharmacology, therapeutic use* Dihydropyridines / pharmacology, therapeutic use* Disease Progression Female Humans Kidney Diseases / drug therapy*, physiopathology Male Middle Aged Prospective Studies Proteinuria / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Dihydropyridines; 3337-17-5/1,4-dihydropyridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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