Document Detail

Calcium channel blockers versus ACE inhibitors as antihypertensives in polycystic kidney disease.
MedLine Citation:
PMID:  8730344     Owner:  NLM     Status:  MEDLINE    
The effects of calcium channel blockers (CCBs) and angiotensin converting enzyme (ACE) inhibitors on blood pressure and the progression of renal dysfunction were compared in hypertensive patients with polycystic kidney disease (PKD). Twenty-six patients with PKD and hypertension who had been treated with other antihypertensive agents, such as diuretics, beta-blockers, or alpha-methyldopa, were followed up for two years, during which their blood pressure and renal function were monitored. Patients were divided into two groups classified according to the type of antihypertensive agents given. Group 1 (n = 14) received CCBs, while group 2 (n = 12) received ACE inhibitors. No significant differences were found in their blood pressure control and serum creatinine levels throughout the study. The creatinine clearances were decreased in both groups. However, the decreases in creatinine clearance were smaller (p < 0.05) in the group treated with CCBs. In addition, two patients in group 2 showed rapid increases in serum creatinine. Our data suggest that CCBs reduced blood pressure effectively and preserved renal function in PKD patients at least as well as ACE inhibitors.
Y Kanno; H Suzuki; H Okada; T Takenaka; T Saruta
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  89     ISSN:  1460-2725     ISO Abbreviation:  QJM     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Department of Internal Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use*
Captopril / therapeutic use
Enalapril / therapeutic use
Hypertension / complications,  drug therapy*
Middle Aged
Nicardipine / therapeutic use
Nifedipine / therapeutic use
Polycystic Kidney Diseases / complications*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine; 62571-86-2/Captopril; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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