| Calcium channel blockade in dialysis patients with left ventricular hypertrophy and well-preserved systolic function. | |
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MedLine Citation:
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PMID: 2455129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Echocardiographic evidence of left ventricular hypertrophy with well-preserved systolic function was established in 4 chronic hemodialysis patients with a history of refractory pulmonary congestion. In each patient a trial of treatment with verapamil (40 mg t.i.d.) resulted in symptomatic improvement, an increase in nadir intradialysis blood pressure, and a marked reduction in intradialytic symptomatic hypertensive episodes and the need for intravenous saline administration. These data suggest that (a) a subset of chronic hemodialysis patients with refractory congestive heart failure and dialysis-related hypotension have hypertrophic cardiomyopathy with well-preserved systolic function, and (b) such patients may derive greater benefit from verapamil treatment than from the more conventional approach to drug therapy with digoxin and nitrates. |
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Authors:
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P K Whelton; A J Watson; B Kone; N J Fortuin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 10 Suppl 10 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-08-04 Completed Date: 1988-08-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S185-6 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Johns Hopkins University School of Hygiene, Baltimore, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Body Weight Cardiomegaly / drug therapy*, etiology, physiopathology Cardiomyopathy, Dilated / drug therapy, etiology, physiopathology Echocardiography Female Heart / anatomy & histology Humans Kidney Failure, Chronic / complications*, physiopathology Middle Aged Renal Dialysis* Systole Verapamil / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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