| Calcium-channel blockade can mask the diagnosis of Conn's syndrome. | |
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MedLine Citation:
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PMID: 10715768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 30-year-old woman presented with hypertension and hypokalaemia, and was found to have primary aldosteronism due to a Conn's adenoma, whose removal cured the hypertension. Before surgery, the characteristic biochemical changes which enabled the diagnosis were completely masked by administration of a calcium-channel blocker, amlodipine. It is likely that widespread use of this class of drugs contributes to under-diagnosis of Conn's syndrome as a curable cause of hypertension. |
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Authors:
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M J Brown; R V Hopper |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Postgraduate medical journal Volume: 75 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1999 Apr |
Date Detail:
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Created Date: 2000-04-13 Completed Date: 2000-04-13 Revised Date: 2009-10-22 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 235-6 Citation Subset: IM |
Affiliation:
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Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amlodipine / therapeutic use* Biological Markers / blood Calcium Channel Blockers / therapeutic use* Electrolytes / blood Female Humans Hyperaldosteronism / complications*, diagnosis Hypertension / drug therapy, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Calcium Channel Blockers; 0/Electrolytes; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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