Document Detail


Calcium binding proteins in motoneurons at low and high risk for degeneration in ALS.
MedLine Citation:
PMID:  11059892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent reports challenge the hypothesis that expression of calcium binding proteins contributes to the greater resistance of some motoneurons to degeneration in amyotrophic lateral sclerosis (ALS). We therefore re-examined, using immunohistochemistry, the expression of calbindin, calretinin and parvalbumin in vulnerable (hypoglossal, XII; and cervical spinal) and resistant (oculomotor, III) motoneurons of adult rats. Calbindin immunoreactivity was lacking in motor nuclei but strong in the dorsal horn. Calretinin was expressed in spinal, but not III or XII, motoneurons. Parvalbumin immunoreactivity, tested with a polyclonal antibody, was intense in spinal and III, but not XII, motoneurons; however, no staining in the ventral horn was observed with a monoclonal antibody. Differential expression of calretinin and parvalbumin within vulnerable motoneurons suggests that immunoreactivity for these proteins is not a reliable marker for resistance to degeneration in ALS.
Authors:
P Laslo; J Lipski; L F Nicholson; G B Miles; G D Funk
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  11     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-29     Completed Date:  2001-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3305-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Amyotrophic Lateral Sclerosis / metabolism*
Animals
Calcium-Binding Protein, Vitamin D-Dependent / metabolism*
Female
Hypoglossal Nerve / cytology,  metabolism*
Immunohistochemistry
Male
Motor Neurons / metabolism*
Oculomotor Nerve / cytology,  metabolism
Parvalbumins / metabolism*
Rats
Rats, Wistar
Risk
Spinal Cord / cytology,  metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Parvalbumins; 0/calbindin; 0/calretinin

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