| Calcium binding proteins in motoneurons at low and high risk for degeneration in ALS. | |
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MedLine Citation:
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PMID: 11059892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent reports challenge the hypothesis that expression of calcium binding proteins contributes to the greater resistance of some motoneurons to degeneration in amyotrophic lateral sclerosis (ALS). We therefore re-examined, using immunohistochemistry, the expression of calbindin, calretinin and parvalbumin in vulnerable (hypoglossal, XII; and cervical spinal) and resistant (oculomotor, III) motoneurons of adult rats. Calbindin immunoreactivity was lacking in motor nuclei but strong in the dorsal horn. Calretinin was expressed in spinal, but not III or XII, motoneurons. Parvalbumin immunoreactivity, tested with a polyclonal antibody, was intense in spinal and III, but not XII, motoneurons; however, no staining in the ventral horn was observed with a monoclonal antibody. Differential expression of calretinin and parvalbumin within vulnerable motoneurons suggests that immunoreactivity for these proteins is not a reliable marker for resistance to degeneration in ALS. |
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Authors:
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P Laslo; J Lipski; L F Nicholson; G B Miles; G D Funk |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 11 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-01-29 Completed Date: 2001-02-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3305-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyotrophic Lateral Sclerosis
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metabolism* Animals Calcium-Binding Protein, Vitamin D-Dependent / metabolism* Female Hypoglossal Nerve / cytology, metabolism* Immunohistochemistry Male Motor Neurons / metabolism* Oculomotor Nerve / cytology, metabolism Parvalbumins / metabolism* Rats Rats, Wistar Risk Spinal Cord / cytology, metabolism* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Parvalbumins; 0/calbindin; 0/calretinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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