| Calcium antagonists and heat-induced hepatic injury. | |
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MedLine Citation:
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PMID: 2890236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several laboratories have demonstrated the value of the isolated perfused rat liver as a suitable model for heat-induced hepatic injury in vivo. Membrane changes caused by perfusion of rat livers at 42 degrees C for 90 min were similar to those induced by toxic chemicals or hypoxia. In an evaluation of several categories of drugs reported to reduce cell injury, calcium antagonists (nifedipine, dantrolene, and verapamil), were evaluated for their therapeutic potential for heat injury. Isolated rat livers were perfused at 42 degrees C for 90 min with and without calcium antagonists. Livers were also perfused at 37 degrees C. Potassium and transaminase leakage, bile production and ultrastructure were used to evaluate their responses. Neither of the three calcium antagonists significantly improved any of the functional parameters measured. However, dantrolene produced dilated or vesicular rough endoplasmic reticulum in the heated livers. These changes suggest selective intracellular action on endoplasmic reticulum of heated livers. Ring-shaped mitochondria and vesicular endoplasmic reticulum were observed in the heated, verapamil-treated livers, but these could not be quantitatively distinguished from controls. Nifedipine did not appear to alter intracellular membranes, but did increase bile production. |
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Authors:
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W Bowers; P Daum; M Blaha; C Stevens; I Castro; I Leav |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Virchows Archiv. B, Cell pathology including molecular pathology Volume: 53 ISSN: 0340-6075 ISO Abbreviation: Virchows Arch., B, Cell Pathol. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-12-11 Completed Date: 1987-12-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9316922 Medline TA: Virchows Arch B Cell Pathol Incl Mol Pathol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 235-42 Citation Subset: IM |
Affiliation:
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U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760-5007. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartate Aminotransferases / analysis Bile / secretion Calcium Channel Blockers / pharmacology* Dantrolene / pharmacology Hyperthermia, Induced / adverse effects* Liver / drug effects*, ultrastructure Male Microscopy, Electron Nifedipine / pharmacology Perfusion Rats Verapamil / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 52-53-9/Verapamil; 7261-97-4/Dantrolene; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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