Document Detail

Calcium antagonists--adverse drug interactions.
MedLine Citation:
PMID:  2908714     Owner:  NLM     Status:  MEDLINE    
In the clinical management of heart disease, calcium channel blockers are generally prescribed in combination with one or more anti-angina, antiarrhythmic, or antihypertensive agents. Two different mechanisms are involved in drug interactions: pharmacokinetic and pharmacodynamic. In the former, the disposition of one drug is altered by the action of another, causing an increase or decrease in its absorption or its modified distribution, metabolism, or excretion. In pharmacodynamic interactions, the physiologic effects of one drug interfere either directly or indirectly with those of another, for instance, by alterations in fluid or electrolyte balance. This effect may be antagonistic or additive. The present work outlines the possible adverse interactions between the three main calcium antagonists and other therapeutic agents, including digoxin, beta blockers and antiarrhythmic, anesthetic, antihypertensive, antiasthmatic, and antidiabetic drugs and contrast media. Knowledge of these effects is of major clinical importance in the treatment of cardiac patients.
H Reicher-Reiss; H N Neufeld; F X Ebner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  1     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1991-05-01     Completed Date:  1991-05-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
Heart Institute, Tel Aviv University, Israel.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Anti-Arrhythmia Agents / pharmacokinetics,  pharmacology
Antihypertensive Agents / pharmacology
Calcium Channel Blockers / pharmacokinetics*
Digoxin / pharmacology
Drug Interactions
Middle Aged
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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