| Calcium antagonists--adverse drug interactions. | |
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MedLine Citation:
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PMID: 2908714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the clinical management of heart disease, calcium channel blockers are generally prescribed in combination with one or more anti-angina, antiarrhythmic, or antihypertensive agents. Two different mechanisms are involved in drug interactions: pharmacokinetic and pharmacodynamic. In the former, the disposition of one drug is altered by the action of another, causing an increase or decrease in its absorption or its modified distribution, metabolism, or excretion. In pharmacodynamic interactions, the physiologic effects of one drug interfere either directly or indirectly with those of another, for instance, by alterations in fluid or electrolyte balance. This effect may be antagonistic or additive. The present work outlines the possible adverse interactions between the three main calcium antagonists and other therapeutic agents, including digoxin, beta blockers and antiarrhythmic, anesthetic, antihypertensive, antiasthmatic, and antidiabetic drugs and contrast media. Knowledge of these effects is of major clinical importance in the treatment of cardiac patients. |
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Authors:
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H Reicher-Reiss; H N Neufeld; F X Ebner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 1 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1991-05-01 Completed Date: 1991-05-01 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 403-9 Citation Subset: IM |
Affiliation:
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Heart Institute, Tel Aviv University, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Animals Anti-Arrhythmia Agents / pharmacokinetics, pharmacology Antihypertensive Agents / pharmacology Calcium Channel Blockers / pharmacokinetics* Digoxin / pharmacology Drug Interactions Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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