Document Detail


Calcium-activated potassium channels, cardiogenesis of pluripotent stem cells, and enrichment of pacemaker-like cells.
MedLine Citation:
PMID:  22626246     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Potassium channels represent the largest group of pore proteins regulating K(+)efflux from the K(+)-rich inner cell to the extracellular compartment, thereby inducing changes in the membrane potential. Activity is regulated either by voltage or calcium concentrations, thus the nomenclature of voltage- and calcium-activated potassium channels. The critical role of potassium ion channels in developmental processes remains enigmatic, although it is well accepted that cell differentiation and maturation affect the expression patterns of certain ion channels. Recently, a series of studies delineated the precise function of calcium-activated potassium channels during cardiac, particularly pacemaker, cell development using human and mouse pluripotent stem cell models. It has become evident that this protein family not only regulates proliferation, apoptosis, and cell metabolism but also drives critical events during organ development such as the heart. This review summarizes the literature on calcium-activated potassium channels, their role in cardiac stem cell differentiation and development, and provides an outlook on how this process could be mechanistically regulated.
Authors:
Alexander Kleger; Stefan Liebau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  21     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Internal Medicine, Ulm University Hospital, 89081 Ulm, Germany.
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