| The Calcium Carbonate Breath Test, a noninvasive test of stimulated gastric acid secretion: preliminary communication. | |
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MedLine Citation:
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PMID: 19279471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gastric acid secretion is subject to complex control mechanisms, and varies widely between individuals and populations. Its measurement has previously required intubation of the stomach with ingestion of a test meal or injection of a secretion stimulant. AIM: We describe a novel method of measuring gastric acid secretion noninvasively - the Calcium Carbonate Breath Test. METHODS: 13C-labelled calcium carbonate is ingested by a fasting participant. The carbonate neutralizes gastric acid to produce 13CO2, which is expired in the breath. Measurement of the excess 13CO2 in the breath allows back-calculation of the amount of gastric acid secreted during the test, provided that other variables affecting CO2 production and excretion are minimized or controlled for. RESULTS: Studies on a single healthy individual have shown reproducible estimations of acid secretion and over 80% suppression of acid secretion after the proton pump inhibitor treatment. CONCLUSION: The method seems to be promising, but further studies on other individuals need to be carried out. The Calcium Carbonate Breath Test may have wide applications in epidemiological studies, clinical management of acid-related diseases, screening for hypochlorhydria and development of new acid-suppressing treatments. |
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Authors:
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Michael R I Clough; Anthony T R Axon |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 21 ISSN: 1473-5687 ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-12 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 266-72 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, The General Infirmary at Leeds, Leeds, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breath Tests
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methods* Calcium Carbonate / administration & dosage, diagnostic use* Carbon Dioxide / analysis Carbon Isotopes / diagnostic use Dose-Response Relationship, Drug Gastric Acid / secretion* Gastric Acidity Determination* Humans Omeprazole / pharmacology Proton Pump Inhibitors / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Proton Pump Inhibitors; 124-38-9/Carbon Dioxide; 471-34-1/Calcium Carbonate; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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