Document Detail

Calcitriol: a better option than vitamin D in denosumab-treated patients with kidney failure?
MedLine Citation:
PMID:  23265605     Owner:  NLM     Status:  MEDLINE    
Denosumab has been proven to be at least as effective with respect to zoledronic acid in preventing skeletal-related events in patients with bone metastases from solid tumors. Although denosumab can be considered to have a more favorable toxicity profile compared to zoledronic acid in terms of kidney toxicity and flu-like symptoms, hypocalcemia is twice as frequent with denosumab. Importantly, denosumab is not metabolized by the kidney and it may be employed even in patients with severe kidney failure. Like zoledronic acid, denosumab is administered with oral calcium and vitamin D. As conversion of vitamin D to its active form is progressively impaired with a creatinine clearance < 70 ml/min, we speculate that calcitriol may be a better option than vitamin D in denosumab-treated patients with impaired kidney function.
Carlo Buonerba; Michele Caraglia; Simona Malgieri; Francesco Perri; Davide Bosso; Piera Federico; Matteo Ferro; Mimma Rizzo; Giovannella Palmieri; Giuseppe Di Lorenzo
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Publication Detail:
Type:  Editorial     Date:  2012-12-25
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  13     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-06-19     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  149-51     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal, Humanized / therapeutic use*
Calcitriol / administration & dosage*
RANK Ligand / antagonists & inhibitors
Renal Insufficiency / drug therapy*
Vitamin D / administration & dosage*
Reg. No./Substance:
0/Antibodies, Monoclonal, Humanized; 0/RANK Ligand; 1406-16-2/Vitamin D; 4EQZ6YO2HI/denosumab; FXC9231JVH/Calcitriol
Comment In:
Expert Opin Biol Ther. 2014 Jan;14(1):137   [PMID:  24266625 ]
Expert Opin Biol Ther. 2014 Jan;14(1):138

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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