| Calcitonin stimulation of cyclic adenosine 3':5'-monophosphate production with growth inhibition in human renal adenocarcinoma cell lines. | |
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MedLine Citation:
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PMID: 2992768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Responsiveness of cyclic adenosine 3':5'-monophosphate (cAMP) to parathyroid hormone, calcitonin, and vasopressin was studied in six human renal adenocarcinoma cell lines. Four of six renal adenocarcinoma cell lines showed increased cAMP content in response to calcitonin while the other two did not. Neither parathyroid hormone nor vasopressin increased the concentration of cAMP in each of these cell lines. The growth rate of KU-2 cells, which responded to calcitonin with an increase of cAMP content, was inhibited by calcitonin. On the other hand the growth rate of calcitonin-nonsensitive KH-39 cells was unaltered. The growth inhibitory effect of the hormone on KU-2 cells could be considered to be mediated by the increased cAMP levels from the following results: (a) there was positive correlation between the cellular cAMP content and growth inhibition after various amounts of calcitonin addition; (b) KU-2 growth was also suppressed by N6,O2'-dibutyryl cAMP; and (c) a group of KU-2 cells which had become resistant to calcitonin-induced growth inhibition showed a diminished cAMP increase in response to calcitonin. |
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Authors:
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Y Kinoshita; M Fukase; M Takenaka; M Nakada; A Miyauchi; T Fujita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer research Volume: 45 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-23 Completed Date: 1985-10-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4890-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism*,
pathology Calcitonin / pharmacology* Cell Line Cyclic AMP / biosynthesis* Humans Kidney Neoplasms / metabolism*, pathology Parathyroid Hormone / pharmacology Vasopressins / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 11000-17-2/Vasopressins; 60-92-4/Cyclic AMP; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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