Document Detail


Calcitonin releases acid phosphatase from rat ventral prostate explants.
MedLine Citation:
PMID:  8107534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inclusion of salmon calcitonin in the culture medium of rat ventral prostate explants diminished l-tartarate-sensitive acid phosphatase activity in the tissues with a concomitant increment of the enzyme activity in the medium. The effect of the hormone was dose-dependent for a dose range of 10(-12)-10(-6) M. Acid phosphatase activity in prostate explants decreased from 38.6 +/- 3.5 to 20.5 +/- 2.8, whereas it increased from 0.60 +/- 0.15 to 2.80 +/- 0.40 nmol p-nitrophenol liberated/mg protein/30 min in the culture medium. Tissues exposed to 10(-6) M salmon calcitonin had higher acetylcholinesterase activity (8.8 +/- 0.7) than non-exposed ones (6.2 +/- 0.5 mumol substrate hydrolyzed/g tissue/min). These results suggest that locally produced calcitonin causes a release for prostatic acid phosphatase from prostate tissues possibly through its interaction with the cholinergic system.
Authors:
A Latif; A M Nakhla
Related Documents :
20803584 - Corozalic acid: a key okadaic acid biosynthetic precursor with phosphatase inhibition a...
477774 - Acid phosphatase in normal human blood cells: characterization by isoelectric focusing ...
3742984 - Electrophoresis of human alkaline and acid phosphatases.
22737434 - The effect of calendula officinalis in therapy of acetic acid induced ulcerative coliti...
14725464 - Diastereoselective electrochemical carboxylation of chiral alpha-bromocarboxylic acid d...
11456114 - Amino acid sequence and characterization of a rice bran ribonuclease.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  54     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1994  
Date Detail:
Created Date:  1994-03-18     Completed Date:  1994-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  561-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Cairo University, Giza, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism
Acid Phosphatase / metabolism*
Animals
Calcitonin / pharmacology*
Culture Media
Culture Techniques
Dose-Response Relationship, Drug
Male
Prostate / drug effects*,  enzymology
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Culture Media; 47931-85-1/salmon calcitonin; 9007-12-9/Calcitonin; EC 3.1.1.7/Acetylcholinesterase; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in the lipid content of rat lymph after the ingestion of [14C] long-chain fatty acids.
Next Document:  Protection of mitochondrial and heart function by amino acids after ischemia and cardioplegia.