Document Detail

Calcitonin releases acid phosphatase from rat ventral prostate explants.
MedLine Citation:
PMID:  8107534     Owner:  NLM     Status:  MEDLINE    
Inclusion of salmon calcitonin in the culture medium of rat ventral prostate explants diminished l-tartarate-sensitive acid phosphatase activity in the tissues with a concomitant increment of the enzyme activity in the medium. The effect of the hormone was dose-dependent for a dose range of 10(-12)-10(-6) M. Acid phosphatase activity in prostate explants decreased from 38.6 +/- 3.5 to 20.5 +/- 2.8, whereas it increased from 0.60 +/- 0.15 to 2.80 +/- 0.40 nmol p-nitrophenol liberated/mg protein/30 min in the culture medium. Tissues exposed to 10(-6) M salmon calcitonin had higher acetylcholinesterase activity (8.8 +/- 0.7) than non-exposed ones (6.2 +/- 0.5 mumol substrate hydrolyzed/g tissue/min). These results suggest that locally produced calcitonin causes a release for prostatic acid phosphatase from prostate tissues possibly through its interaction with the cholinergic system.
A Latif; A M Nakhla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  54     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1994  
Date Detail:
Created Date:  1994-03-18     Completed Date:  1994-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  561-5     Citation Subset:  IM    
Department of Biochemistry, Cairo University, Giza, Egypt.
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MeSH Terms
Acetylcholinesterase / metabolism
Acid Phosphatase / metabolism*
Calcitonin / pharmacology*
Culture Media
Culture Techniques
Dose-Response Relationship, Drug
Prostate / drug effects*,  enzymology
Rats, Sprague-Dawley
Reg. No./Substance:
0/Culture Media; 47931-85-1/salmon calcitonin; 9007-12-9/Calcitonin; EC; EC Phosphatase

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