Document Detail

Calcitonin receptor and Odz4 are differently expressed in Pax7-positive cells during skeletal muscle regeneration.
MedLine Citation:
PMID:  22562803     Owner:  NLM     Status:  Publisher    
Satellite cells, muscle-specific stem cells, are anatomically identified as the mononuclear cells residing external to the myofiber plasma membrane and beneath the basal lamina. Skeletal muscle has great regenerative potential, and the regeneration process depends absolutely on satellite cells. In uninjured muscle, satellite cells are maintained in a quiescent state, and some genes are expressed in a quiescent-specific manner. Here we show that Odz4/Ten-m4, a mouse homolog of the Drosophila pair-rule gene odd Oz (odz or Ten-m), is expressed in quiescent satellite cells on the protein level, but not in activated/proliferating myoblasts. Intriguingly, the timing of the reappearance of Odz4 and calcitonin receptor (another quiescence molecule) on Pax7-positive cells was different during the regeneration process. In addition, almost all neonatal satellite cells express Odz4, but only some of them express calcitonin receptor. These results indicate that Odz4 may be useful as a new marker of satellite cells and that quiescence molecules are differently expressed in regenerating and neonatal muscle.
Masahiko Yamaguchi; Ryo Ogawa; Yoko Watanabe; Akiyoshi Uezumi; Yuko Miyagoe-Suzuki; Kazutake Tsujikawa; Hiroshi Yamamoto; Shin'ichi Takeda; So-Ichiro Fukada
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-5
Journal Detail:
Title:  Journal of molecular histology     Volume:  -     ISSN:  1567-2387     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101193653     Medline TA:  J Mol Histol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan.
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