| Calcitonin measurement on fine needle washouts: Preanalytical Issues and Normal Reference Values. | |
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MedLine Citation:
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PMID: 22144096 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Calcitonin (CT) measurement on fine-needle aspiration cytology (FNAC) washouts (FNAC-CT) is a promising tool in the diagnosis of medullary thyroid carcinoma (MTC). Guidelines for the method with codified cut-off are needed to use this technique in clinical routine. This study was undertaken to assess the best pre-analytical procedure and to define a reliable reference value for FNAC-CT. Fifty-four patients underwent thyroid surgery, so MTC was excluded by surgical pathology examination and CT immunostains. Before surgery, FNAC-CT was measured on 78 thyroid nodules from such 54 patients. Needles were rinsed by normal saline and specific CT-free dilution buffer, and CT was measured by a fully automated immunochemiluminometric assay. FNAC-CT levels were not significantly different in normal saline or specific buffer. The calculated 97.5th upper FNAC-CT value was 8.5 pg/mL (saline) and 7.43 pg/mL (buffer), respectively. Seeing its relatively large sample size, rigorous selection criteria and inclusion of CT immunostaining of thyroid nodules, the present study provides a reliable guideline and a clinically relevant reference value for FNAC-CT measurement in thyroid nodules. Diagn. Cytopathol. 2011; © 2011 Wiley Periodicals, Inc. |
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Authors:
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Luca Giovanella; Luca Ceriani; Massimo Bongiovanni |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
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Title: Diagnostic cytopathology Volume: - ISSN: 1097-0339 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506895 Medline TA: Diagn Cytopathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland; Department of Clinical Chemistry and Laboratory Medicine, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, Switzerland. luca.giovanella@eoc.ch. |
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