| Calcitonin gene-related peptide increases coronary flow and decreases coronary resistance. | |
| | |
MedLine Citation:
|
PMID: 2246888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Calcitonin gene-related peptide (CGRP) is a potent vasodilator, but its effects on in situ ventricular function are unknown. We studied effects of intracoronary CGRP (100, 200, and 600 pmole/min, for 10 min) in 21 open-chest chloralose-anesthetized dogs. Systemic, pulmonary, left ventricular (LVP), central venous, and pulmonary capillary wedge pressures were continuously monitored. Left ventricular wall thickness (WT) and circumflex coronary blood flow were also measured. CGRP was infused into the proximal circumflex artery. During CGRP infusion there were no changes in heart rate, cardiac index, pulmonary artery pressure, or systemic vascular resistance, no percentage change in ventricular WT, and no changes in dWT/dt, peak dP/dt, or the slope of end-systolic points on WT/LVP loops. But there were significant changes in coronary flow (CQ), coronary resistance (CRES) and mean arterial blood pressure (MAP) from control (C)* (P less than 0.05). (table; see text) CGRP is a potent coronary artery vasodilator causing notable dose-dependent decreases in coronary resistance and a rise in myocardial flow, despite a decreased MAP (all P less than 0.05). CGRP does not affect ventricular contractility in vivo. |
| | |
Authors:
|
C D Joyce; R A Prinz; J X Thomas; R R Fiscus; X A Wang; G Djuricin; H K Jacobs |
Related Documents
:
|
1148088 - Systemic and coronary haemodynamic effects of ketamine in intact anaesthetized and unan... 6865468 - Comparison of distribution beyond coronary stenoses of blood and asanguineous cardiople... 9780618 - Nitrate tolerance in patients with effort angina. 6421078 - Nitrous oxide augments the systemic and coronary haemodynamic effects of isoflurane in ... 9864018 - Pulmonary hypertension in high-altitude chronic hypoxia: response to nifedipine. 8001108 - Use of cutoff pigtail catheters with intraluminal guidewires in interventional procedur... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of surgical research Volume: 49 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1990 Nov |
Date Detail:
|
Created Date: 1991-01-08 Completed Date: 1991-01-08 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 435-40 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Calcitonin Gene-Related Peptide / blood, pharmacology* Coronary Circulation / drug effects* Coronary Vessels / drug effects*, physiology Dogs Dose-Response Relationship, Drug Myocardial Contraction / drug effects Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
|
83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Iodine toxicity secondary to continuous povidone-iodine mediastinal irrigation in dogs.
Next Document: Plasma albumin repletion after transfusion with polymerized hemoglobin.