| Calcitonin gene-related peptide in human fetal lung and in neonatal lung disease. | |
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MedLine Citation:
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PMID: 3257223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ontogeny of calcitonin gene-related peptide immunoreactivity (CGRP-IR) was evaluated immunohistochemically in 67 human fetal or newborn lungs previously analyzed for calcitonin immunoreactivity (CT-IR). CGRP-IR was present by 10 weeks of gestation in rare, solitary neuroendocrine (NE) cells of developing conducting airways in two of eight first-trimester lungs. During the second trimester, cells with CGRP-IR were found consistently (21/23 fetuses). However, the numbers of positively staining cells did not appear to increase in these fetuses or in third-trimester infants dying of non-pulmonary causes. The highest concentrations of CGRP-IR cells were seen in lungs of premature infants with advancing chronic lung disease associated with bronchopulmonary dysplasia (BPD). CGRP-IR was seen earlier in gestation and in greater numbers of NE cells than was calcitonin immunoreactivity (CT-IR) reported previously in these same fetal lungs (Lab Invest 52:52, 1985). Its presence paralleled that of CT-IR in postnatal chronic lung disease. |
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Authors:
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M D Johnson; M E Gray; M T Stahlman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Volume: 36 ISSN: 0022-1554 ISO Abbreviation: J. Histochem. Cytochem. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-02-24 Completed Date: 1988-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9815334 Medline TA: J Histochem Cytochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Pathology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchopulmonary Dysplasia
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metabolism Calcitonin Gene-Related Peptide Female Fetus / metabolism* Humans Hyaline Membrane Disease / metabolism Infant, Newborn Lung / embryology, metabolism* Lung Diseases / embryology, metabolism* Neuropeptides / metabolism* Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second |
| Grant Support | |
ID/Acronym/Agency:
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HL 14214/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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