Document Detail


Calcitonin gene-related peptide in human fetal lung and in neonatal lung disease.
MedLine Citation:
PMID:  3257223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ontogeny of calcitonin gene-related peptide immunoreactivity (CGRP-IR) was evaluated immunohistochemically in 67 human fetal or newborn lungs previously analyzed for calcitonin immunoreactivity (CT-IR). CGRP-IR was present by 10 weeks of gestation in rare, solitary neuroendocrine (NE) cells of developing conducting airways in two of eight first-trimester lungs. During the second trimester, cells with CGRP-IR were found consistently (21/23 fetuses). However, the numbers of positively staining cells did not appear to increase in these fetuses or in third-trimester infants dying of non-pulmonary causes. The highest concentrations of CGRP-IR cells were seen in lungs of premature infants with advancing chronic lung disease associated with bronchopulmonary dysplasia (BPD). CGRP-IR was seen earlier in gestation and in greater numbers of NE cells than was calcitonin immunoreactivity (CT-IR) reported previously in these same fetal lungs (Lab Invest 52:52, 1985). Its presence paralleled that of CT-IR in postnatal chronic lung disease.
Authors:
M D Johnson; M E Gray; M T Stahlman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  36     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-02-24     Completed Date:  1988-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Affiliation:
Department of Pathology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.
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MeSH Terms
Descriptor/Qualifier:
Bronchopulmonary Dysplasia / metabolism
Calcitonin Gene-Related Peptide
Female
Fetus / metabolism*
Humans
Hyaline Membrane Disease / metabolism
Infant, Newborn
Lung / embryology,  metabolism*
Lung Diseases / embryology,  metabolism*
Neuropeptides / metabolism*
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Grant Support
ID/Acronym/Agency:
HL 14214/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptides; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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