Document Detail

Calcitonin gene-related peptide in patients with and without early reperfusion after acute myocardial infarction.
MedLine Citation:
PMID:  1462896     Owner:  NLM     Status:  MEDLINE    
Plasma concentrations of calcitonin gene-related peptide (CGRP), a potent regulator of vascular tone, creatine kinase, myoglobin, and cardiac troponin T were assessed in 31 patients with acute myocardial infarction. In patients who had sustained acute myocardial infarctions, maximum CGRP concentrations (median, 3.2 pmol/L; interquartile range, 1.5 to 4.8 pmol/L) were markedly elevated as compared with healthy control subjects (n = 23; median, 1.02 pmol/L; p = 0.02). However, no marked differences in CGRP levels were observed between patients with early reperfusion (n = 19; median, 3.5 pmol/L) and patients without early reperfusion (n = 12; median, 2.6 pmol/L; p = 0.96), as well as between those with congestive heart failure (n = 8; median, 3.9 pmol/L) and those without congestive heart failure (n = 23; median, 3.2 pmol/L; p = 0.62). CGRP did not correlate closely with myocardial protein release or hemodynamic parameters (heart rate and blood pressure) or the occurrence of arrhythmias. Therefore we conclude that elevated peripheral venous CGRP concentrations in patients who have sustained an acute myocardial infarction are independent of successful reperfusion and hemodynamic state. Although the cause of CGRP increase is not yet identified, CGRP may play a role in the regulation of coronary vascular tone in patients after acute myocardial infarction.
P Lechleitner; N Genser; J Mair; A Dienstl; C Haring; C J Wiedermann; B Puschendorf; A Saria; F Dienstl
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  124     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-12     Completed Date:  1993-01-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1433-9     Citation Subset:  AIM; IM    
Department of Internal Medicine, University of Innsbruck, Austria.
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MeSH Terms
Aged, 80 and over
Calcitonin Gene-Related Peptide / blood*
Case-Control Studies
Creatine Kinase / blood
Heart Failure / blood,  etiology
Middle Aged
Myocardial Infarction / blood*,  complications,  drug therapy
Myoglobin / blood
Streptokinase / therapeutic use
Thrombolytic Therapy*
Time Factors
Troponin / blood
Troponin T
Urokinase-Type Plasminogen Activator / therapeutic use
Reg. No./Substance:
0/Myoglobin; 0/Troponin; 0/Troponin T; 83652-28-2/Calcitonin Gene-Related Peptide; EC Kinase; EC 3.4.-/Streptokinase; EC Plasminogen Activator

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