Document Detail

Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxia.
MedLine Citation:
PMID:  12220731     Owner:  NLM     Status:  MEDLINE    
Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasorelaxant peptides. This study examined exercise-induced changes in CGRP and AM levels in 12 healthy sea level natives at sea level (SL) and subsequently after 24 h (HA1) and 5 days (HA5) in high altitude hypoxia (4559 m). Plasma values of CGRP, AM, calcitonin, noradrenaline, adrenaline, lactate and heart rate were measured at rest and during maximal exercise (W(max)). On each study day, the dopamine D(2)-receptor antagonist, domperidone (30 mg; n=6), or no medication (n=6) was given 1 h before exercise. W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. The maximal CGRP levels at W(max) were significantly decreased at HA1 (74.3+/-6.1 pmol/l; p=0.002) and HA5 (69.6+/-6.0 pmol/l; p<0.001) compared to maximal CGRP at SL (85.1+/-4.9 pmol/l). A similar pattern was observed for lactate and the relation between CGRP and lactate release showed a close linear correlation (r(2)=0.63, P<0.0001). Domperidone produced a marked increase in noradrenaline at W(max), but had no affect on CGRP or AM. In conclusion, CGRP release during hypoxic exercise does not respond to domperidone-induced changes in circulating levels of noradrenaline, rather the release may be directly related to the production of lactate.
Philip Hasbak; Carsten Lundby; Niels Vidiendal Olsen; Søren Schifter; Inge-Lis Kanstrup
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  108     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2003-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, University Hospital of Herlev, Herlev, Denmark.
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MeSH Terms
Altitude Sickness / physiopathology
Calcitonin / blood
Calcitonin Gene-Related Peptide / blood,  secretion*
Domperidone / pharmacology
Dopamine Antagonists / pharmacology
Epinephrine / blood
Exercise / physiology*
Heart Rate / drug effects,  physiology*
Lactates / blood
Norepinephrine / blood
Peptides / blood,  secretion*
Reference Values
Reg. No./Substance:
0/Dopamine Antagonists; 0/Lactates; 0/Peptides; 148498-78-6/Adrenomedullin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57808-66-9/Domperidone; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-12-9/Calcitonin

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