| Calcitonin gene-related peptide (CGRP) and capsaicin-induced stimulation of heart contractile rate and force. | |
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MedLine Citation:
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PMID: 3878946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of calcitonin gene-related peptide (CGRP) on guinea-pig heart contractility were investigated in vitro in relation to the response of capsaicin and noradrenaline (NA). Synthetic rat CGRP (greater than 10(-8) M) caused a long-lasting, positive inotropic and chronotropic effect on the spontaneously beating right atrium. The response to CGRP mimicked the effects of capsaicin and was resistant to beta-adrenoceptor blockade using metoprolol. Furthermore, CGRP did not change basal efflux or the release of 3H-NA induced by transmural nerve stimulation, suggesting an action independent of sympathetic mechanisms. Mepyramine and cimetidine did not reduce the response to CGRP. After tachyphylaxis to the effects of CGRP (5 X 10(-7) M) which developed within 15-20 min, the positive inotropic and chronotropic atrial response to capsaicin was abolished. The effects of NA, however, were not influenced by CGRP tachyphylaxis. In the isolated perfused whole heart, CGRP had more pronounced stimulatory effects on ventricular contractile rate than on force compared to NA. The CGRP response was resistant to metoprolol and still present in capsaicin-pretreated animals. Capsaicin caused a slight initial inhibition of ventricular contractility, which was followed by a marked stimulatory action. As for CGRP, the cardioexcitatory response to capsaicin was more pronounced on rate than on force. The stimulatory responses to capsaicin were absent 2 weeks after systemic capsaicin pretreatment. In conclusion, CGRP mimics the non-adrenergic, cardioexcitatory effects of capsaicin, and the capsaicin response is absent after CGRP tachyphylaxis.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Franco-Cereceda; J M Lundberg |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 331 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1986-03-03 Completed Date: 1986-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 146-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcitonin Gene-Related Peptide Capsaicin / pharmacology* Guinea Pigs Heart / innervation Heart Atria / drug effects Heart Rate / drug effects* Heart Ventricles / drug effects Male Myocardial Contraction / drug effects* Nerve Tissue Proteins / pharmacology* Norepinephrine / metabolism, pharmacology Perfusion |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 404-86-4/Capsaicin; 51-41-2/Norepinephrine; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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