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Calcitonin gene-related peptide (CGRP) - microadenomas of the thyroid gland induced by cadmium toxicity. Experimental study.
MedLine Citation:
PMID:  21766506     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: The objective of our study was to make morphological and functional analysis of thyroid C cells in rats chronically exposed to cadmium (Cd). Methods: The study was carried out on female albino Wistar rats (n=22, age=35-37 days, body mass 120-140 g), divided in control (n=11) and experimental group (n=11). The rats of the experimental group were treated with 15 mg/kg Cd dissolved (as CdCl(2)) in drinking water. The animals were sacrificed 3 months later. The thyroid glands were removed and macroscopic, histological and immunocytochemical examinations were done. Monoclonal antibodies for chromogranin A (Chr A), neuron specific enolase (NSE), calcitonin (CT), somatostatin (SST) and calcitonin gene related peptide (CGRP) were used for immunocytochemical examinations. Results: No pathological changes were found in parafollicular cells of the animals of the control group. All the animals of the experimental group showed bilateral diffuse C cell hyperplasia, mostly in the middle and upper thirds of the lobes. Strong immunoreactivity was present to all tested polypeptides (Chr A, CT, NSE, CGRP and SST). In 5 (45%) of the animals of the experimental group, C cell microadenomas were exclusively made of CGRP-secreting cells. Conclusion: Chronic Cd exposure causes preneoplastic changes and functional differentiation of parafollicular cells of the thyroid gland, the first cell type being present in the area of diffuse hyperplasia, and the other C cell type being the constituent of microadenomas secreting CGRP exclusively. The results of this study indicate that chronic Cd exposure disturbs the structure and function of C cells of the thyroid gland.
Authors:
S Jancic; V Bojanic; G Rancic; I Joksimovic; N Jancic; M Zindovic; V Stankovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of B.U.ON. : official journal of the Balkan Union of Oncology     Volume:  16     ISSN:  1107-0625     ISO Abbreviation:  J BUON     Publication Date:    2011 Apr-Jun
Date Detail:
Created Date:  2011-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883428     Medline TA:  J BUON     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  331-6     Citation Subset:  IM    
Affiliation:
Institute for Pathology, Faculty of Medicine University of Kragujevac, Kragujevac, Serbia.
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