| Calcitonin assay in wash-out fluid after fine-needle aspiration biopsy in patients with a thyroid nodule and border-line value of the hormone. | |
| | |
MedLine Citation:
|
PMID: 19636196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Assaying calcitonin (CT) in the wash-out fluid from fine-needle aspiration biopsies (CT-FNAB) could be useful in the diagnosis of medullary thyroid carcinoma (MTC). The aim of this study was to correlate serum CT with cytology and CT-FNAB. Twenty-seven subjects (age range 27-75 yr) were studied. FNAB was performed in a thyroid nodule (no.=16) or lymph-node (no.=1 previously operated on for MTC) or in the prevalent nodule of multinodular goiters (no.=10). CT-FNAB values obtained in 37 subjects with normal serum CT (<10 ng/l) who underwent FNAB for thyroid nodules served as a negative control. In these subjects, CTFNAB values were 8.2+/-6.4 ng/l (range 2-30 ng/l). In patients with a thyroid nodule under evaluation for MTC, serum CT and CT-FNAB values were 14.5+/-3.9 ng/l (range 10-24 ng/l) and 16.4+/-29.8 ng/l (range 2-144 ng/l), respectively. In 4 patients, CT-FNAB values were higher than the highest values found in our negative controls (30 ng/l), but cytology results were compatible with a benign thyroid lesion and pentagastrin testing was negative. In 3 cases with CT-FNAB <30 ng/l, cytology was indicative of an indeterminate or probably follicular malignant lesion and histology was negative for MTC. None of the other subjects in whom pentagastrin testing was conducted showed serum CT values >100 ng/l. Our data do not show any correlation between CT-FNAB and serum CT. In conclusion, borderline CT values in patients with thyroid nodules are not rare. Our experience suggests that CT-FNAB does not have the same importance as that reported in the literature for thyroglobulin and PTH assay in wash-out fluid after FNAB in malignant thyroid and hyperfunctioning parathyroid lesions. |
| | |
Authors:
|
F Massaro; M Dolcino; R Degrandi; D Ferone; M Mussap; F Minuto; M Giusti |
Related Documents
:
|
21482916 - Reversible cerebral vasoconstriction syndromes: analysis of 139 cases. 21337426 - Cross-sectional and longitudinal reproducibility of rhesus macaque brain metabolites: a... 1868656 - Tl-201 thyroid imaging in differentiating benign from malignant thyroid nodules. 7485376 - A pigmented adenoma of the ciliary epithelium examined by magnetic resonance imaging. 16166916 - Anatomy and imaging of lumbar plexus. 21972076 - Determination of cranio-spinal canal compliance distribution by mri: methodology and ea... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of endocrinological investigation Volume: 32 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-07-28 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
|
Languages: eng Pagination: 308-12 Citation Subset: IM |
Affiliation:
|
Department of Immuno-Endocrinological Pathology, San Martino University Hospital, Genoa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Biological Assay Biopsy, Fine-Needle Body Fluids / metabolism Calcitonin / metabolism* Carcinoma, Medullary / metabolism, pathology* Female Humans Lymph Nodes Lymphatic Metastasis Male Middle Aged Retrospective Studies Thyroid Gland / metabolism Thyroid Nodule / metabolism, pathology* Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrom...
Next Document: Adrenocorticotropin-independent Cushing's syndrome in pregnancy related to overexpression of adrenal...