| Calcitonin and CGRP block bombesin- and substance P-induced increases in airway tone. | |
| | |
MedLine Citation:
|
PMID: 2468637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Calcitonin gene-related peptide (CGRP) and calcitonin (C) are two peptides that are cocontained and probably coreleased with the potent bronchocontrictors, bombesin (B) and substance P (SP), within the lung. Although CGRP and C have a wide intrapulmonary distribution, their actions have not been well defined. By the use of a computerized lung mechanics analyzer, changes in response to 10-min infusions of these agents were measured in spontaneously breathing, anesthetized guinea pigs. Infusion of 0.3 nmol.kg-1.min-1 CGRP and 2 nmol.kg-1.min-1 C caused little change in lung mechanics. Infusion of 0.06 nmol.kg-1.min-1 B and 0.3 nmol.kg-1.min-1 SP caused a marked increase in inspiratory, expiratory, and total pulmonary resistance (RT), from base-line values (P less than 0.02), with a maximal effect at 10 min postinfusion (PI) [RT = 326 +/- 20% (SE) (B), 490 +/- 73% (SP)]. Coinfusion of C or CGRP with B or SP at the above concentrations caused a marked reduction in SP - [RT = 189 +/- 28% (C), 142 +/- 16% (CGRP) at 10 min PI] and B - [RT = 157 +/- 18% (C), 158 +/- 10% (CGRP) at 10 min PI] induced changes in resistance (P less than 0.015). The mode of action of C and CGRP is unknown, but these peptides may antagonize the effects of B and SP via autonomic pathways by interfering with B- or SP-induced changes in intracellular calcium concentrations or by increasing intracellular cAMP levels by binding to specific cellular receptors linked to adenylate cyclase. |
| | |
Authors:
|
C Gatto; R C Lussky; L W Erickson; K J Berg; J D Wobken; D E Johnson |
Related Documents
:
|
20833607 - Short-term changes in respiratory biomarkers after swimming in a chlorinated pool. 12391087 - Tidal volume single-breath washin of sf6 and ch4 in transient microgravity. 8503547 - Physiologic responses and distribution of aerosolized surfactant (survanta) in a nonuni... 1517137 - Bronchial cartilage dysplasia with multifocal lobar bullous emphysema and lung torsions... 7993947 - Validation of cardiac output measurements with noninvasive doppler echocardiography by ... 16800097 - Effect of long-term atorvastatin treatment on the electrophysiological and mechanical f... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 66 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1989 Feb |
Date Detail:
|
Created Date: 1989-06-02 Completed Date: 1989-06-02 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 573-7 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Minnesota, Minneapolis 55455. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Airway Resistance
/
drug effects* Animals Biomechanics Bombesin / antagonists & inhibitors, pharmacology Calcitonin / pharmacology* Calcitonin Gene-Related Peptide Guinea Pigs Lung / drug effects, physiology Male Neuropeptides / pharmacology* Receptors, Calcitonin Receptors, Cell Surface / drug effects, physiology Substance P / antagonists & inhibitors, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
1291//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neuropeptides; 0/Receptors, Calcitonin; 0/Receptors, Cell Surface; 31362-50-2/Bombesin; 33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electrophysiological properties and morphology of hair cells isolated from the semicircular canal of...
Next Document: Enhanced airway responses to substance P after repeated challenge in guinea pigs.