Document Detail

Calcipotriol induces apoptosis in psoriatic keratinocytes.
MedLine Citation:
PMID:  19758385     Owner:  NLM     Status:  MEDLINE    
In recent years, vitamin D3 analogues have become one of the most widely prescribed topical treatments for mild or moderate chronic plaque psoriasis. These molecules are effective and safe, but their exact mechanism of action is not completely understood. In vitro studies have shown that D3 analogues decrease proliferation and induce differentiation of keratinocytes, and have strong immunomodulating effects, but there are no conclusive data about apoptosis. The aim of this study was to evaluate differences in apoptotic response between lesional and perilesional keratinocytes of patients with psoriasis before and after treatment with calcipotriol, a synthetic vitamin D3 analogue. Keratinocytes were isolated from psoriatic plaques including lesional and perilesional skin, and cultured. Cells were treated with calcipotriol for 20 h and examined under confocal microscopy after staining with propidium iodide. The number of apoptotic cells after incubation with calcipotriol was significantly higher in lesional than in perilesional keratinocytes (P < 0.05) or non-treated psoriatic keratinocytes (P < 0.05). In conclusion, calcipotriol seems to induce apoptosis in psoriatic keratinocytes.
R Tiberio; C Bozzo; G Pertusi; F Graziola; M Gattoni; P Griffanti; P Boggio; E Colombo; G Leigheb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-15
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  34     ISSN:  1365-2230     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-08     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e972-4     Citation Subset:  IM    
Dermatologic Clinic, University of Piemonte Orientale A. Avogadro, Novara, Italy.
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MeSH Terms
Apoptosis / drug effects*
Calcitriol / analogs & derivatives*,  pharmacology
Dermatologic Agents / pharmacology*
Keratinocytes / drug effects*,  physiology
Middle Aged
Prospective Studies
Psoriasis / drug therapy*,  pathology
Young Adult
Reg. No./Substance:
0/Dermatologic Agents; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol

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