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MedLine Citation:
PMID:  23551819     Owner:  NLM     Status:  Publisher    
BACKGROUND: Calciphylaxis is an uncommon and often under diagnosed condition affecting patients undergoing chronic dialysis. Its pathogenesis is poorly understood. The abnormalities of calcium, phosphate and parathyroid hormone homeostasis leading to vascular calcification and ischaemic skin necrosis are thought to be the central problem. Meticulous wound care and aggressive metabolic control remain the cornerstone of the treatment; however, the overall benefit of these treatment options remains low and mortality and morbidity remain very high. Sodium thiosulphate is an inorganic salt, which is used for treating acute cyanide poisoning, recurrent calcium urolithiasis and nephrocalcinosis. Recently, it has also been reported to be useful in treating severe cases of calciphylaxis with promising results. METHODS: A resistant case of calciphylaxis in a patient on long-term haemodialysis was treated with sodium thiosulphate (50 ml solution with 50% sodium thiosulphate) three times a week during the end of each dialysis session. RESULTS: The skin lesions started to heal after two weeks and completely resolved after five months of treatment. CONCLUSIONS: Sodium thiosulphate can be a safe and effective treatment option for resistant and severe cases of calciphylaxis.
Robert Burnie; Sarah Smail; Muhammad M Javaid
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-2
Journal Detail:
Title:  Journal of renal care     Volume:  -     ISSN:  1755-6686     ISO Abbreviation:  J Ren Care     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392167     Medline TA:  J Ren Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 European Dialysis and Transplant Nurses Association/European Renal Care Association.
Department of Nephrology, Dartford and Gravesham NHS Trust, Dartford, UK.
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