Document Detail


Calciphylaxis in a patient with end-stage renal disease.
MedLine Citation:
PMID:  11436366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification. It is seen almost exclusively in patients with end-stage renal disease and secondary hyperparathyroidism. We experienced a case of 67-year-old man with calciphylaxis that manifested with characteristic skin lesions, pathologic findings, and laboratory changes. His skin lesions began as painful erythematous patches and subsequently progressed to necrotic ulcers with eschars on the distal aspect of the extremities. Pathologically, calcification was found in small and medium-sized blood vessels in the deep dermis and subcutaneous tissue. His serum calcium was 9.5 mg/dL, phosphorus was 7.8 mg/dL, and nPTH was 99.9 pg/mL. The patient had been treated with surgical debridement and other supportive treatment. However, he eventually underwent an amputation below the right knee and died from sepsis.
Authors:
Y J Kim; B S Chung; K C Choi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  28     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  272-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, College of Medicine, Chosun University, 588, Seosuck-Dong, Dong-Ku, Gwangju 501-140, Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amputation
Calciphylaxis / complications,  diagnosis*,  pathology,  surgery
Diagnosis, Differential
Fatal Outcome
Fingers
Humans
Kidney Failure, Chronic / complications*
Male
Toes

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