| Calcineurin subunit B up-regulates IFN-β production by phosphorylaiton of IRF3 via TLR4. | |
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MedLine Citation:
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PMID: 22118374 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Toll like receptors (TLRs) function as pattern-reorganization receptors in mammals and play an essential role in innate immunity. After recognizing certain ligands, TLRs activate a cascade of signal pathways to establish a guard environment. Here for the first time, we report that in vitro treatment of recombinant calcineurin subunit B (CNB) up-regulated several TLR related genes. CNB interacted with ectodomain of TLR4 in vitro. Upon further investigation, phosphorylation of IRF3 and degradation of IκB-α were observed by CNB stimulation. Besides pro-inflammatory cytokines, transcription and production of IFN-β were also enhanced after CNB stimulation. Thus, CNB can be further explored as a cancer and virus immune therapy drug. |
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Authors:
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Xinyu Wang; Li Li; Yi Huang; Qun Wei |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-26 |
Journal Detail:
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Title: Cancer science Volume: - ISSN: 1349-7006 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Japanese Cancer Association. |
Affiliation:
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Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing 100875, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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