Document Detail

Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature.
MedLine Citation:
PMID:  24037599     Owner:  NLM     Status:  Publisher    
Clear cell calcifying epithelial odontogenic tumour (CCEOT) is a rare variant of calcifying epithelial odontogenic tumor (CEOT). While it is not surprising to find clear cells in odontogenic lesions, the exact nature of the clear cells in CCEOT has not been elucidated. Herein, we report a case of peripheral CCEOT of anterior mandible in a 37 year old black female. Histologically, the tumour consisted of cords and small nests of clear cells surrounded by dense deposits of amyloid and basophilic calcifications. The cells possessed abundant clear cytoplasm and eccentrically located indented nuclei. Admixed with the clear cells were eosinophilic cuboidal to polyhedral cells. The clear cells were PAS negative and immunoreactive for S100 protein, CD1a and Langerin. The clear cells were negative for MNF-116, SMA, Desmin and CK-19. It is therefore recommended to recognize two variants of CCEOT, namely, CEOT with clear cell change and CEOT with clear Langerhans cells (LC). We further suggest that the contradictory term "non-calcifying variant of calcifying epithelial odontogenic tumour with LC" to be abandoned, as the current case clearly indicates that LC could be seen in CEOT irrespective of the presence or absence of calcifications.
Amir Afrogheh; Johann Schneider; Noor Mohamed; Jos Hille
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-14
Journal Detail:
Title:  Head and neck pathology     Volume:  -     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa,
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