Document Detail

Calcified Cartilage Islands in Rat Cortical Bone.
MedLine Citation:
PMID:  23274728     Owner:  NLM     Status:  Publisher    
Rats display little to no haversian remodeling of cortical bone. This fact, combined with the endochondral formation of cortical bone, means that rat femoral cortical bone contains highly mineralized cartilage islands in a central band of mid-femoral cross sections. We demonstrate that these islands have a significantly higher degree of mineralization than the surrounding bone, using quantitative backscattered electron imaging. The cartilaginous nature of the islands was verified by immunostaining for collagen type II. Toluidine blue staining of longitudinal sections and three-dimensional synchrotron radiation X-ray tomographic microscopy confirmed that the islands are elongated along the femoral long axis. Nanoindentation revealed significantly higher values of both reduced modulus and hardness in the islands compared to the surrounding bone, reflecting a higher degree of mineralization. The calcified cartilage islands were distributed in a central zone of the bone, from the growth plates through the mid-femoral bone. The presence of these cartilage islands and their possible effect on mechanical properties could be an additional reason why haversian remodeling is observed in higher-order species.
Fiona Linnea Bach-Gansmo; Sarah Catherine Irvine; Annemarie Brüel; Jesper Skovhus Thomsen; Henrik Birkedal
Related Documents :
24110278 - A meshless local boundary integral equation (lbie) method for cell proliferation predic...
23227798 - Osteogenic activity of yellow flag iris (iris pseudacorus) extract modulating different...
23776188 - Biomimetic composites by surface-initiated polymerization of cyclic lactones at anorgan...
23827368 - Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthr...
24038108 - The effects of a semi-rigid ankle brace on a simulated isolated subtalar joint instabil...
11816018 - Canine prostate induces new bone formation in mouse calvaria: a model of osteoinduction...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-1
Journal Detail:
Title:  Calcified tissue international     Volume:  -     ISSN:  1432-0827     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry and iNANO, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Spanking, corporal punishment and negative long-term outcomes: A meta-analytic review of longitudina...
Next Document:  Potential effects of yohimbine and sildenafil on erectile dysfunction in rats.