Document Detail

Calcific aortic valve and spontaneous embolic stroke: a review of literature.
MedLine Citation:
PMID:  19712938     Owner:  NLM     Status:  MEDLINE    
Aortic valve calcification is common in the elderly and in patients with congenital bicuspid aortic valve but unlike calcific mitral valve disease it is not a well recognized risk factor for stroke. Although autopsy studies have revealed evidence of systemic embolism in one-third of cases with calcific aortic valves, there is conflicting data from larger clinical studies examining the association between calcific aortic valve and stroke. There are only 8 reported cases of symptomatic stroke from spontaneous cerebral thromboembolism associated with calcific aortic valve in the literature. Computerized tomography (CT) angiography and CT without contrast are modalities of choice to diagnose calcific embolism, while MRI may be useful in delineating the extent of ischemia. Ideal management strategy, the role of antiplatelet therapy, anticoagulation or recommendations for valve replacements are poorly defined. We present a focused literature review on this topic.
Vipin Khetarpal; Nitin Mahajan; Ramesh Madhavan; Sachin Batra; Prashanth Mopala; Amit Sagar; Praveen Rapolu; Sharad Nangia; Luis Afonso
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-26
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  287     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
Division of Cardiology, Wayne State University, Detroit, MI-48201, USA.
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MeSH Terms
Anticoagulants / adverse effects,  therapeutic use
Aortic Valve Stenosis / diagnosis*,  epidemiology*,  therapy
Calcinosis / diagnosis,  epidemiology,  therapy
Cardiac Surgical Procedures / standards
Cerebral Hemorrhage / chemically induced,  prevention & control
Diagnostic Imaging / standards
Intracranial Embolism / diagnosis*,  epidemiology*,  therapy
Platelet Aggregation Inhibitors / therapeutic use
Stroke / diagnosis*,  epidemiology*,  therapy
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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