Document Detail

Calcific aortic stenosis: a complication of chronic uraemia.
MedLine Citation:
PMID:  3696315     Owner:  NLM     Status:  MEDLINE    
The incidence of aortic stenosis was studied in 174 consecutive patients aged less than 55 years at initiation of maintenance haemodialysis. Severe, calcific aortic stenosis developed in 6 patients a mean 9.7 years after starting haemodialysis (p = 0.0004 compared to population incidence). In 5 patients stenosis was due to severe premature calcification of a tricuspid aortic valve. Necropsy proven aortic valve calcification (with or without stenosis) was associated with an increased duration of haemodialysis, age greater than 35 years at starting dialysis and mitral annular calcification. There is an increased incidence of aortic stenosis in patients with chronic renal failure due to premature valvular calcification, which may be related to abnormal calcium and phosphate metabolism in uraemia.
E R Maher; M Pazianas; J R Curtis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  47     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-27     Completed Date:  1988-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Department of Medicine, Charing Cross Hospital, London, UK.
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MeSH Terms
Age Factors
Aortic Valve Stenosis / epidemiology,  etiology*
Calcinosis / complications*,  epidemiology
Kidney Failure, Chronic / complications
Middle Aged
Renal Dialysis / adverse effects
Time Factors
Uremia / complications*

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