Document Detail


Calcifediol in chronic renal insufficiency. Skeletal response.
MedLine Citation:
PMID:  946022     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative histology of thin, nondecalcified sections was performed on sequential bone biopsy specimens from five patients undergoing long-term hemodialysis and treated with calcifediol (25-hydroxycholecalciferol) for periods of three to nine months. With increase of intestinal absorption of calcium and decline of circulating immunoreactive parathyroid hormone and alkaline phosphatase, the bones of each patient exhibited striking histological improvement. The group as a whole showed statistically significant decreases in osteoclast number and in the percentages of osteoid surface covered by active osteoblasts. Marrow fibrosis was either eliminated or strikingly decreased in each patient. Osteoid volume significantly declined in four of five patients. In patients with osteitis fibrosa as the predominant histological lesion, calcifediol therapy resulted in decreased calcification front activity. Increased activity was the result when osteomalacia predominated.
Authors:
S L Teitelbaum; J M Bone; P M Stein; J J Gilden; M Bates; V C Boisseau; L V Avioli
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  235     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-02-26     Completed Date:  1976-02-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkaline Phosphatase / blood
Biopsy
Bone and Bones / drug effects*,  enzymology
Calcium / metabolism
Female
Humans
Hydroxycholecalciferols / pharmacology*,  therapeutic use
Intestinal Absorption / drug effects
Kidney Failure, Chronic / drug therapy*,  therapy
Male
Middle Aged
Parathyroid Hormone / blood
Renal Dialysis
Renal Osteodystrophy / prevention & control
Time Factors
Chemical
Reg. No./Substance:
0/Hydroxycholecalciferols; 0/Parathyroid Hormone; EC 3.1.3.1/Alkaline Phosphatase; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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