Document Detail

Calcaneal ultrasound attenuation and vitamin-D-receptor genotypes in celiac disease.
MedLine Citation:
PMID:  10720115     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Osteopenia is common in patients with celiac disease and is believed to result from malnutrition. Osteoporosis in otherwise healthy individuals is related to genetically determined polymorphisms within the vitamin-D-receptor (VDR) gene. We hypothesized that in celiac patients particular genes of the VDR enhance the susceptibility for malnutrition-associated low-bone density. METHODS: We determined allelic frequencies within the VDR gene by restriction fragment length polymorphism analysis in 92 patients with celiac disease (age, 15-83 years). Thirty-eight patients were on a gluten-free diet; 54 patients did not adhere to a diet. The determined VDR polymorphisms in 111 unrelated newborns served as controls. Osteopenia was determined by means of ultrasound measurements of the calcaneus (n = 78). Bone turnover was estimated by osteocalcin determination (n = 60). RESULTS: There was no difference in the frequency of the VDR gene polymorphisms in patients with celiac disease compared with controls. Adjusted ultrasound measures of the calcaneus were low in 47% of patients, but there was no difference of the VDR gene frequencies in these patients compared with those with normal ultrasound results or controls. Bone turnover was higher in patients without a gluten-free diet (P = 0.02). Again, there was no association with any particular VDR gene. CONCLUSIONS: Patients with celiac disease frequently have osteopenia, which is not related to any of the determined genes within the VDR.
H Vogelsang; E K Suk; M Janisiw; C Stain; W R Mayr; S Panzer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  35     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-07     Completed Date:  2000-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  172-6     Citation Subset:  IM    
Clinic of Internal Medicine IV, Dept. of Gastroenterology and Hepatology, University of Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Bone Density*
Bone Diseases, Metabolic / etiology*,  genetics,  ultrasonography
Bone Remodeling / physiology
Calcaneus / physiology,  ultrasonography
Case-Control Studies
Celiac Disease / complications,  genetics*,  physiopathology
Diet Therapy
Infant, Newborn
Middle Aged
Receptors, Calcitriol / genetics*
Risk Factors
Vitamin D Deficiency
Reg. No./Substance:
0/Receptors, Calcitriol

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