| The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice. | |
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MedLine Citation:
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PMID: 20363211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CagA protein is the most assessed effecter molecule of Helicobacter pylori. In this report, we demonstrate how CagA protein regulates the functions of dendritic cells (DC) against H. pylori infection. In addition, we found that CagA protein was tyrosine-phosphorylated in DC. The responses to cagA-positive H. pylori in DC were reduced in comparison to those induced by cagA-negative H. pylori. CagA-overexpressing DC also exhibited a decline in the responses against LPS stimulation and the differentiation of CD4(+) T cells toward Th1 type cells compared to wild type DC. In addition, the level of phosphorylated IRF3 decreased in CagA-overexpressing DC stimulated with LPS, indicating that activated SHP-2 suppressed the enzymatic activity of TBK1 and consequently IRF3 phosphorylation. These data suggest that CagA protein negatively regulates the functions of DC via CagA phosphorylation and that cagA-positive H. pylori strains suppress host immune responses resulting in their chronic colonization of the stomach. |
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Authors:
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Hiroshi Tanaka; Masaru Yoshida; Shin Nishiumi; Naomi Ohnishi; Kazuki Kobayashi; Koji Yamamoto; Tsuyoshi Fujita; Masanori Hatakeyama; Takeshi Azuma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-02 |
Journal Detail:
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Title: Archives of biochemistry and biophysics Volume: 498 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 35-42 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Kobe University, Chu-o-ku, Hyogo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Bacterial / chemistry, genetics, immunology*, metabolism Bacterial Proteins / chemistry, genetics, immunology*, metabolism Bone Marrow Cells / cytology CD4-Positive T-Lymphocytes / immunology Cell Differentiation / drug effects, immunology Cytokines / biosynthesis Dendritic Cells / cytology, immunology*, metabolism, microbiology* Epithelial Cells / immunology, microbiology, pathology Helicobacter pylori / physiology* Immunosuppressive Agents / chemistry, immunology*, metabolism Interferon Regulatory Factor-3 / metabolism Mice Mice, Inbred C57BL Mice, Transgenic Phosphorylation / immunology Stomach / microbiology, pathology Stomach Neoplasms / immunology, microbiology, pathology Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Cytokines; 0/Immunosuppressive Agents; 0/Interferon Regulatory Factor-3; 0/Irf3 protein, mouse; 0/cagA protein, Helicobacter pylori; 55520-40-6/Tyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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