Document Detail


Caffeine: an update.
MedLine Citation:
PMID:  7344909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While the total annual volume of caffeine has increased over the years, the actual per capita daily intake has not. This is based on the fact that the quantity of caffeine in a soft drink is about the same or, in the case of diet drinks, less than in 1961 when the original GRAS (Generally Recognized as Safe) determinations were made. Since that time, there have been numerous studies on the effect of caffeine on animals and humans. The Select Committee on GRAS Substances (SCOGS) of the Federation of American Societies for Experimental Biology (FASEB) in 1978 reviewed all the data available at that time and concluded that there is "no evidence in the available information on caffeine [that] demonstrates a hazard to the public when it is used in cola-type beverages at levels that are now current and in the manner now practiced...", although they did suggest further study was necessary. The Flavor and Extract Manufacturers' Association (FEMA) Expert Panel has now reviewed not only the same data s the FASEB (SCOGS) Committee, but several more recent studies. On the basis of this review, the Panel reaffirms the GRAS status of caffeine under conditions of its current use as an international ingredient in nonalcoholic beverages.
Authors:
B L Oser; R A Ford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  4     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1981  
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-29     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology
Adolescent
Adult
Animals
Behavior / drug effects
Caffeine / administration & dosage,  adverse effects*,  metabolism*
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Kinetics
Mice
Middle Aged
Neoplasms / chemically induced
Pregnancy
Rats
Reproduction / drug effects
Chemical
Reg. No./Substance:
58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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