Document Detail


Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2.
MedLine Citation:
PMID:  16391865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of pulmonary adenocarcinoma (PAC) has increased dramatically over the last three decades. Recent studies have shown that human PAC cells with phenotypic features of bronchiolar Clara cells and experimentally induced PAC of Clara cell origin are under beta-adrenergic growth control. The phosphodiesterase inhibitor, theophylline, which is contained in tea, asthma/allergy medications and numerous dietary supplements selectively stimulated the growth of this cancer type in vivo and in vitro. The current study has tested the hypothesis that another environmentally prominent phosphodiesterase inhibitor, caffeine, has similar effects. Using a cell line derived from a human PAC with Clara cell features (PACC) and immortalized human small airway epithelial cells (SAECs), our data show that caffeine activated protein kinase A (PKA), the mitogen-activated kinases ERK1/2, the nuclear transcription factor cyclic AMP response element binding protein (CREB) and stimulated cell proliferation in these cell lines. These findings suggest that exposure to caffeine may contribute to the prevalence of PAC observed today.
Authors:
Hussein A N Al-Wadei; Takashi Takahashi; Hildegard M Schuller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  15     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-06-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
Affiliation:
Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / enzymology*
Blotting, Western
CREB-Binding Protein / drug effects,  metabolism
Caffeine / pharmacology*
Cell Line, Tumor
Central Nervous System Stimulants / pharmacology*
Cyclic AMP-Dependent Protein Kinases
Enzyme Activation / drug effects*
Epithelial Cells / drug effects*
Extracellular Signal-Regulated MAP Kinases / drug effects,  metabolism
Humans
Lung Neoplasms / enzymology*
Protein-Serine-Threonine Kinases / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 58-08-2/Caffeine; EC 2.3.1.48/CREB-Binding Protein; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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