Document Detail

Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2.
MedLine Citation:
PMID:  16391865     Owner:  NLM     Status:  MEDLINE    
The incidence of pulmonary adenocarcinoma (PAC) has increased dramatically over the last three decades. Recent studies have shown that human PAC cells with phenotypic features of bronchiolar Clara cells and experimentally induced PAC of Clara cell origin are under beta-adrenergic growth control. The phosphodiesterase inhibitor, theophylline, which is contained in tea, asthma/allergy medications and numerous dietary supplements selectively stimulated the growth of this cancer type in vivo and in vitro. The current study has tested the hypothesis that another environmentally prominent phosphodiesterase inhibitor, caffeine, has similar effects. Using a cell line derived from a human PAC with Clara cell features (PACC) and immortalized human small airway epithelial cells (SAECs), our data show that caffeine activated protein kinase A (PKA), the mitogen-activated kinases ERK1/2, the nuclear transcription factor cyclic AMP response element binding protein (CREB) and stimulated cell proliferation in these cell lines. These findings suggest that exposure to caffeine may contribute to the prevalence of PAC observed today.
Hussein A N Al-Wadei; Takashi Takahashi; Hildegard M Schuller
Related Documents :
16817605 - Effects of polystyrene particle density on type ii pneumocytes.
10338535 - Macrophages and epithelial cells respond differently to the pseudomonas aeruginosa type...
2462755 - Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human ...
2822825 - Neutrophil chemotactic activity produced by normal and activated human bronchoalveolar ...
12119175 - Sodium butyrate stimulates the synthesis of firefly luciferase in transfected cho cells...
22138605 - Evaluation of cell death after treatment with extracorporeal photopheresis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  15     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-06-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / enzymology*
Blotting, Western
CREB-Binding Protein / drug effects,  metabolism
Caffeine / pharmacology*
Cell Line, Tumor
Central Nervous System Stimulants / pharmacology*
Cyclic AMP-Dependent Protein Kinases
Enzyme Activation / drug effects*
Epithelial Cells / drug effects*
Extracellular Signal-Regulated MAP Kinases / drug effects,  metabolism
Lung Neoplasms / enzymology*
Protein-Serine-Threonine Kinases / drug effects,  metabolism
Reg. No./Substance:
0/Central Nervous System Stimulants; 58-08-2/Caffeine; EC Protein; EC Kinases; EC AMP-Dependent Protein Kinases; EC Signal-Regulated MAP Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mib-1 proliferation index is an independent predictor of lymph node metastasis in invasive breast ca...
Next Document:  Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung...