Document Detail

Caffeine and psychiatric medication interactions: a review.
MedLine Citation:
PMID:  16206866     Owner:  NLM     Status:  MEDLINE    
Caffeine can cause or worsen psychiatric symptoms but also has the potential to interact with many psychiatric medications. This article provides a literature review regarding interactions between caffeine and psychiatric medications. Caffeine is metabolized by the CYP1A2 enzyme and also acts as a competitive inhibitor of this enzyme. Thus, caffeine can interact with a wide range of psychiatric medications, including antidepressant agents, antipsychotic agents, antimanic agents, antianxiety agents, and sedative agents. These interactions may lead to caffeine-related or medication-related side effects that may complicate psychiatric treatment. By recognizing this potential, along with educating the patient, and utilizing a tapering approach, prevention of caffeine interactions is achievable.
Pamela J Broderick; Ashley B Benjamin; Leland W Dennis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of the Oklahoma State Medical Association     Volume:  98     ISSN:  0030-1876     ISO Abbreviation:  J Okla State Med Assoc     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-10-06     Completed Date:  2005-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503043     Medline TA:  J Okla State Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-4     Citation Subset:  IM    
University of Oklahoma, USA.
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MeSH Terms
Anti-Anxiety Agents / adverse effects,  pharmacology
Antidepressive Agents / adverse effects,  pharmacology
Antimanic Agents / adverse effects,  pharmacology
Antipsychotic Agents / adverse effects,  pharmacology
Caffeine / adverse effects*,  pharmacology
Drug Interactions
Hypnotics and Sedatives / adverse effects,  pharmacology
Medical History Taking
Psychotropic Drugs / adverse effects*,  pharmacology
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Antimanic Agents; 0/Antipsychotic Agents; 0/Hypnotics and Sedatives; 0/Psychotropic Drugs; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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