| Caffeine and paraxanthine pharmacokinetics in the rabbit: concentration and product inhibition effects. | |
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MedLine Citation:
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PMID: 3612497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The disposition of caffeine (C) and its major metabolite paraxanthine (P) have been determined following i.v. bolus dosing both separately and concomitantly to New Zealand White rabbits. Caffeine clearances of 1.52-6.71 ml/min/kg were observed and were suggestive of polymorphism with rapid (type I) and slow (type II) metabolizing subpopulations represented. Type II metabolizers exhibited dose-independent pharmacokinetics for C, while the clearances of type I animals were dose-dependent (lower clearances at higher doses). The P clearances were not dose-dependent. In type I rabbits coadministration of P inhibited C metabolism by as much as 71%. Results were consistent with the hypothesis that at least two forms of cytochrome "P-450" mediate the metabolism of C in the rabbit. |
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Authors:
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S H Dorrbecker; R A Ferraina; B R Dorrbecker; P A Kramer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of pharmacokinetics and biopharmaceutics Volume: 15 ISSN: 0090-466X ISO Abbreviation: J Pharmacokinet Biopharm Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-08-28 Completed Date: 1987-08-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0357115 Medline TA: J Pharmacokinet Biopharm Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 117-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caffeine / metabolism* Female Half-Life Kinetics Protein Binding Rabbits Theophylline / metabolism*, pharmacology Ultrafiltration |
| Grant Support | |
ID/Acronym/Agency:
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HD 16900/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine; 58-55-9/Theophylline; 611-59-6/1,7-dimethylxanthine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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