Document Detail


Caffeine and miscarriage risk.
MedLine Citation:
PMID:  18091004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Coffee and caffeine have been inconsistently found to be associated with increased risk of clinical miscarriage-a potentially important association given the high prevalence of exposure. METHODS: Women were recruited before or early in pregnancy and interviewed regarding sources of caffeine, including assessment of changes over the perinatal period. We identified 2407 clinically-recognized pregnancies resulting in 258 pregnancy losses. We examined the relationship of coffee and caffeine intake with clinically-recognized pregnancy loss prior to 20 weeks' completed gestation, using a discrete-time continuation ratio logistic survival model. RESULTS: Coffee and caffeine consumption at all 3 time points were unrelated to total miscarriage risk and the risk of loss after the interview. Reported exposure at the time of the interview was associated with increased risk among those with losses before the interview. CONCLUSIONS: There is little indication of possible harmful effects of caffeine on miscarriage risk within the range of coffee and caffeine consumption reported, with a suggested reporting bias among women with losses before the interview. The results may reflect exposure misclassification and unmeasured heterogeneity of pregnancy losses.
Authors:
David A Savitz; Ronna L Chan; Amy H Herring; Penelope P Howards; Katherine E Hartmann
Related Documents :
11750784 - The impact of prenatal stress, fetal alcohol exposure, or both on development: perspect...
24334424 - Chemerin concentrations in maternal and fetal compartments: implications for metabolic ...
20955784 - Developmental exposure to tcdd reduces fertility and negatively affects pregnancy outco...
277064 - Dietary cravings and aversions during pregnancy.
17727124 - Maternal folate status and neural tube defects in ireland: the need for a national food...
2750894 - Calciotrophic hormone levels and calcium absorption during pregnancy in rats.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  19     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-19     Completed Date:  2008-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Affiliation:
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. david.savitz@mssm.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology*
Adolescent
Adult
Caffeine / adverse effects*
Coffee / adverse effects*
Female
Humans
Interviews as Topic
Middle Aged
North Carolina / epidemiology
Nutrition Surveys
Odds Ratio
Pregnancy
Risk Factors
Tennessee / epidemiology
Texas / epidemiology
Grant Support
ID/Acronym/Agency:
ES07018/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Coffee; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Longitudinal determinants of posttraumatic stress in a population-based cohort study.
Next Document:  Residential outdoor air pollution and lung function in schoolchildren.