| Caffeine and miscarriage risk. | |
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MedLine Citation:
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PMID: 18091004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coffee and caffeine have been inconsistently found to be associated with increased risk of clinical miscarriage-a potentially important association given the high prevalence of exposure. METHODS: Women were recruited before or early in pregnancy and interviewed regarding sources of caffeine, including assessment of changes over the perinatal period. We identified 2407 clinically-recognized pregnancies resulting in 258 pregnancy losses. We examined the relationship of coffee and caffeine intake with clinically-recognized pregnancy loss prior to 20 weeks' completed gestation, using a discrete-time continuation ratio logistic survival model. RESULTS: Coffee and caffeine consumption at all 3 time points were unrelated to total miscarriage risk and the risk of loss after the interview. Reported exposure at the time of the interview was associated with increased risk among those with losses before the interview. CONCLUSIONS: There is little indication of possible harmful effects of caffeine on miscarriage risk within the range of coffee and caffeine consumption reported, with a suggested reporting bias among women with losses before the interview. The results may reflect exposure misclassification and unmeasured heterogeneity of pregnancy losses. |
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Authors:
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David A Savitz; Ronna L Chan; Amy H Herring; Penelope P Howards; Katherine E Hartmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 19 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-19 Completed Date: 2008-02-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 55-62 Citation Subset: IM |
Affiliation:
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Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. david.savitz@mssm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology* Adolescent Adult Caffeine / adverse effects* Coffee / adverse effects* Female Humans Interviews as Topic Middle Aged North Carolina / epidemiology Nutrition Surveys Odds Ratio Pregnancy Risk Factors Tennessee / epidemiology Texas / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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ES07018/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coffee; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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