Document Detail

Caffeine intake and pregnancy outcomes: a meta-analytic review.
MedLine Citation:
PMID:  9761606     Owner:  NLM     Status:  MEDLINE    
Epidemiological publications on the relationship of caffeine to birth weight and duration of human pregnancy, from 1966 to 1995, were searched through Medline. Each study was treated as the stratification variable, and its weight average was proportional to the inverse of its variance. Twenty-six studies were located. Among the twenty-two studies on birth weight, eleven were on mean birth weight, nine on low birth weight (LBW), and four on intrauterine growth retardation (IUGR). Combined analysis of mean birth weight study results showed a significant decrease in birth weight of nearly 43g among newborns of the heaviest caffeine-consuming mothers. LBW, IUGR, and preterm delivery displayed significant homogeneity in the test results, indicating that a pooled estimate should not be taken as na adequate measure. The high heterogeneity of the available literature on the effects of caffeine on LBW, IUGR, and preterm delivery prevents estimation of reliable pooled estimates through meta-analysis. Further assessment of caffeine intake during pregnancy is needed in future research.
I S Santos; C G Victora; S Huttly; S Morris
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis    
Journal Detail:
Title:  Cadernos de saúde pública     Volume:  14     ISSN:  0102-311X     ISO Abbreviation:  Cad Saude Publica     Publication Date:    1998 Jul-Sep
Date Detail:
Created Date:  1998-11-24     Completed Date:  1998-11-24     Revised Date:  2013-03-18    
Medline Journal Info:
Nlm Unique ID:  8901573     Medline TA:  Cad Saude Publica     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  523-30     Citation Subset:  IM    
Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Caixa Postal 464, Pelotas, RS, 96001-970, Brasil.
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MeSH Terms
Birth Weight
Caffeine / adverse effects*
Confidence Intervals
Fetal Growth Retardation
Infant, Low Birth Weight
Infant, Newborn
Obstetric Labor, Premature
Pregnancy Outcome*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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