Document Detail

Caffeine and glucose homeostasis during rest and exercise in diabetes mellitus.
MedLine Citation:
PMID:  23855268     Owner:  NLM     Status:  In-Data-Review    
Caffeine is a substance that has been used in our society for generations, primarily for its effects on the central nervous system that causes wakefulness. Caffeine supplementation has become increasingly more popular as an ergogenic aid for athletes and considerable scientific evidence supports its effectiveness. Because of their potential to alter energy metabolism, the effects of coffee and caffeine on glucose metabolism in diabetes have also been studied both epidemiologically and experimentally. Predominantly targeting the adenosine receptors, caffeine causes alterations in glucose homeostasis by decreasing glucose uptake into skeletal muscle, thereby causing elevations in blood glucose concentration. Caffeine intake has also been proposed to increase symptomatic warning signs of hypoglycemia in patients with type 1 diabetes and elevate blood glucose levels in patients with type 2 diabetes. Other effects include potential increases in glucose counterregulatory hormones such as epinephrine, which can also decrease peripheral glucose disposal. Despite these established physiological effects, increased coffee intake has been associated with reduced risk of developing type 2 diabetes in large-scale epidemiological studies. This review paper highlights the known effects of caffeine on glucose homeostasis and diabetes metabolism during rest and exercise.
Dessi P Zaharieva; Michael C Riddell
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Publication Detail:
Type:  Journal Article     Date:  2013-05-14
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  38     ISSN:  1715-5320     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  813-22     Citation Subset:  IM    
School of Kinesiology and Health Science and Muscle Health Research Centre, York University, 347 Bethune College, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
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