Document Detail

Caffeine dose-dependently potentiates the antitumor effect of cisplatin on osteosarcomas.
MedLine Citation:
PMID:  18630526     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Caffeine-assisted chemotherapy has been used in the treatment of osteosarcomas. However, there is little in vivo evidence for this treatment, and thus we sought to verify the dose and effect of caffeine in combination with cisplatin in osteosarcoma-bearing rats. MATERIALS AND METHODS: Seven-week-old male Fischer rats were transplanted with chemical carcinogen-induced osteosarcoma, selected lung metastatic lesions tumor block. The osteosarcoma-bearing rats were treated with saline, caffeine, cisplatin or cisplatin and caffeine. RESULTS: The most growth inhibition was observed in the co-administration group. When three different dosing schedules of caffeine were given, the extent of tumor inhibition was closely correlated with the average plasma concentration of caffeine. The cisplatin concentration in the tumor was significantly increased when caffeine was co-administered. CONCLUSION: This study confirms that a high concentration of caffeine (about 0.4 mM) is effective in enhancing the antitumor effects of cisplatin.
Masami Kawahara; Yuri Takahashi; Kotaro Takazawa; Hiroyuki Tsuchiya; Katsuro Tomita; Koichi Yokogawa; Ken-ichi Miyamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  28     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1681-5     Citation Subset:  IM    
Department of Hospital Pharmacy, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / blood,  pharmacokinetics,  pharmacology*
Bone Neoplasms / blood,  drug therapy*,  metabolism
Caffeine / administration & dosage,  blood,  pharmacology*
Cisplatin / administration & dosage,  blood,  pharmacokinetics,  pharmacology*
Dose-Response Relationship, Drug
Drug Synergism
Osteosarcoma / blood,  drug therapy*,  metabolism
Rats, Inbred F344
Tissue Distribution
Reg. No./Substance:
15663-27-1/Cisplatin; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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