| Caffeine and the development of the normal and neoplastic mammary gland. | |
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MedLine Citation:
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PMID: 7938026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There has been much interest in the role of dietary factors in the etiology and progression of breast disease. Due to its wide consumption and the many biochemical and physiological effects it exerts, caffeine has been extensively examined in both clinical and experimental animal studies. To date, clinical studies investigating a possible relationship between caffeine consumption and breast disease in humans have yielded inconsistent and inconclusive results. In experimental animal studies utilizing laboratory mice and rats, caffeine has been shown to stimulate mammary gland lobulo-alveolar development and secretion. The development of mammary gland tumors can be either stimulated or suppressed depending upon the animal species and strain, and the stage of tumorigenesis (initiation/promotion) at which caffeine is administered. Many laboratories have proposed that antagonism of the adenosine receptor is the most plausible mechanism to account for the many biological activities of caffeine. However, other mechanisms by which caffeine act cannot be discounted. The significant modifying role of caffeine on normal and neoplastic mammary gland development in experimental animals provides a biological foundation from which to implicate caffeine as a potential modulator of developmental growth of normal, benign, and carcinomatous human breast tissues. |
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Authors:
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C W Welsch |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 207 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1994-11-08 Completed Date: 1994-11-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast Diseases / chemically induced* Breast Neoplasms / chemically induced* Caffeine / adverse effects*, pharmacology Female Mammary Glands, Animal / growth & development Mammary Neoplasms, Experimental / chemically induced* Mice Mice, Inbred BALB C Mice, Inbred C3H Rats Rats, Sprague-Dawley Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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CA37613/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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