Document Detail

Caffeine consumption and methotrexate dosing requirement in psoriasis and psoriatic arthritis.
MedLine Citation:
PMID:  17269967     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent animal and human studies have suggested that the therapeutic benefit of methotrexate in the treatment of rheumatoid arthritis may be substantially reduced in patients who are concomitantly consuming caffeine. Here, we aimed to investigate the effect of caffeine consumption on the methotrexate dosing requirements in patients with psoriasis and psoriatic arthritis. METHODS: One hundred and fifty patients with diagnoses of psoriasis or psoriatic arthritis were surveyed for their current weekly methotrexate dosage and their usual daily consumption of caffeine. RESULTS: Seventy-five of the patients given the survey responded; of these, 11 were eliminated because they did not report their methotrexate dosage or were no longer taking methotrexate. Of the remaining 64 patients, no correlation was found between the methotrexate dosage needed for disease maintenance and the amount of caffeine consumed. CONCLUSIONS: Our findings suggest that caffeine does not affect methotrexate dosage requirements in patients with psoriasis and psoriatic arthritis. These results do not rule out an effect of caffeine in other inflammatory diseases treated with methotrexate.
David L Swanson; Sunni A Barnes; Stephanie J Mengden Koon; Rokea A el-Azhary
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  46     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-9     Citation Subset:  IM    
Department of Dermatology, Mayo Clinic, Scottsdale, Arizona 85259, USA.
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MeSH Terms
Aged, 80 and over
Arthritis, Psoriatic / drug therapy*
Caffeine / pharmacology*
Dermatologic Agents / administration & dosage,  pharmacokinetics*
Drug Interactions
Food-Drug Interactions
Methotrexate / administration & dosage,  pharmacokinetics*
Middle Aged
Psoriasis / drug therapy*
Reg. No./Substance:
0/Dermatologic Agents; 58-08-2/Caffeine; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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