Document Detail

Caffeine and brain development in very preterm infants.
MedLine Citation:
PMID:  21031585     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Caffeine improves neurological outcome in very preterm infants, but the mechanisms responsible for this neurological benefit are unknown. The objective of this study was to assess whether caffeine influenced brain macro- or microstructural development in preterm infants.
METHODS: Seventy preterm infants <1,251 g birthweight randomly allocated to either caffeine (n = 33) or placebo (n = 37) underwent brain magnetic resonance imaging (MRI) at term-equivalent age; white and gray matter abnormalities were qualitatively scored, global and regional brain volumes were measured, and white matter microstructure was evaluated using diffusion-weighted imaging.
RESULTS: There were no significant differences between the groups in the extent of white matter or gray matter abnormality, or in global or regional brain volumes. In contrast, although only available in 28 children, caffeine exposure was associated with reductions in the apparent diffusion coefficient, and radial and axial diffusivity with the greatest impact in the superior brain regions. The alterations in diffusion measures were not mediated by lowering the rate of lung injury, known as bronchopulmonary dysplasia.
INTERPRETATION: These diffusion changes are consistent with improved white matter microstructural development in preterm infants who received caffeine.
Lex W Doyle; Jeanie Cheong; Rod W Hunt; Katherine J Lee; Deanne K Thompson; Peter G Davis; Sandra Rees; Peter J Anderson; Terrie E Inder
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  68     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-29     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  734-42     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects*,  growth & development,  pathology
Bronchopulmonary Dysplasia / pathology,  prevention & control*
Caffeine / therapeutic use*
Central Nervous System Stimulants / therapeutic use*
Diffusion Magnetic Resonance Imaging / methods
Infant, Newborn
Infant, Premature / growth & development*
Nerve Fibers, Myelinated / drug effects,  pathology
Grant Support
Reg. No./Substance:
0/Central Nervous System Stimulants; 3G6A5W338E/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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